Tbio CD300A CMRF35-like molecule 8

Protein Summary

Description

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9UGN4
• A8MW96
• O95100
• Q9HD97
• Q9P0F3
• Q9UBK4
• Q9UMS9
• Q9UMT0
• CLM-8

Gene Name

• CD300A

Ensembl ID

• ENST00000310828
• ENSP00000308188
• ENSG00000167851
• ENST00000360141
• ENSP00000353259
• ENST00000361933
• ENSP00000354564
• ENST00000392625
• ENSP00000376401

Symbol

• CMRF35H
• IGSF12
• IRC1
• IRC2
• CLM-8
• IRp60
• IGSF12
• CMRF35H
• CMRF-35H
• CMRF35-H
• CMRF35H9
• CMRF35-H9
• IRC1/IRC2
• CMRF-35-H9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
kinase perturbation	0.88
transcription factor perturbation	0.74
tissue sample	0.65
cell line	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.16   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.16   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0