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Tbio
CD300A
CMRF35-like molecule 8

Protein Summary
Description
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310828
  • ENSP00000308188
  • ENSG00000167851
  • ENST00000360141
  • ENSP00000353259
  • ENST00000361933
  • ENSP00000354564
  • ENST00000392625
  • ENSP00000376401

Symbol
  • CMRF35H
  • IGSF12
  • IRC1
  • IRC2
  • CLM-8
  • IRp60
  • IGSF12
  • CMRF35H
  • CMRF-35H
  • CMRF35-H
  • CMRF35H9
  • CMRF35-H9
  • IRC1/IRC2
  • CMRF-35-H9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
kinase perturbation
0.88
transcription factor perturbation
0.74
tissue sample
0.65
cell line
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.23   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.23   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD300a molecule
VGNC:9172
468318
Mouse
MGI:2443411
217303
Rat
RGD:1583719
501736
Dog
CMRF35-like molecule 8
483289
Cow
CD300a molecule
516915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD300a molecule
Mouse
Rat
Dog
CMRF35-like molecule 8
Cow
CD300a molecule
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGN4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (158)
1 – 10 of 158
LAIR1
Tbio
Novelty: 0.0133817
Score: 0.961
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.951
Data Source: STRINGDB
CD53
Tbio
Novelty: 0.01722633
Score: 0.95
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.949
Data Source: STRINGDB
FCER1G
Tbio
Novelty: 0.00783146
Score: 0.949
Data Source: STRINGDB
LILRB2
Tbio
Novelty: 0.00545569
Score: 0.943
Data Source: STRINGDB
CEACAM1
Tbio
Novelty: 0.0029954
Score: 0.941
Data Source: STRINGDB
SIRPA
Tbio
Family: Enzyme
Novelty: 0.0021102
Score: 0.936
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.935
Data Source: STRINGDB
CLEC12A
Tbio
Novelty: 0.01478908
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.23

PubMed score by year
PubTator Score  49.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer