Tbio WARS2 Tryptophan--tRNA ligase, mitochondrial

Protein Summary

Description

Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UGM6
• B1ALR1
• B2R9D4
• Q53FT4
• Q5VUD2
• Q86TQ0

Gene Name

• WARS2

Ensembl ID

• ENST00000235521
• ENSP00000235521
• ENSG00000116874
• ENST00000369426
• ENSP00000358434

Symbol

• TrpRS
• NEMMLAS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
virus perturbation	0.92
molecular function	0.88
transcription factor binding site profile	0.84
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.17   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.17   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0