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Tbio
FETUB
Fetuin-B

Protein Summary
Description
Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening (By similarity). The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265029
  • ENSP00000265029
  • ENSG00000090512
  • ENST00000382136
  • ENSP00000371571
  • ENST00000450521
  • ENSP00000404288

Symbol
  • 16G2
  • Gugu
  • IRL685
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
disease perturbation
0.68
gene perturbation
0.67
kinase perturbation
0.66
PubMedID
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.98   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.98   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fetuin B
VGNC:1819
460913
Macaque
fetuin B
699226
Mouse
MGI:1890221
59083
Rat
RGD:69293
83928
Dog
fetuin B
VGNC:40826
478665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fetuin B
Macaque
fetuin B
Mouse
Rat
Dog
fetuin B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGM5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (111)
1 – 10 of 111
ITIH2
Tbio
Novelty: 0.04886358
Score: 0.939
Data Source: STRINGDB
AMBP
Tbio
Novelty: 0.00183885
Score: 0.897
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.867
Data Source: STRINGDB
FGG
Tbio
Novelty: 0.00404457
Score: 0.844
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.841
Data Source: STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.837
Data Source: STRINGDB
GC
Tchem
Novelty: 0.00065382
Score: 0.79
Data Source: STRINGDB
NR1H4
Tclin
Family: NR
Novelty: 0.00067092
Score: 0.787
Data Source: STRINGDB
APOA4
Tbio
Novelty: 0.00305835
Score: 0.769
Data Source: STRINGDB
FTCD
Tbio
Family: Enzyme
Novelty: 0.02266041
Score: 0.74
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.98

PubMed score by year
PubTator Score  20.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer