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Tchem
CHRNA9
Neuronal acetylcholine receptor subunit alpha-9

Protein Classes
Protein Summary
Description
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151). The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion (PubMed:11021840). This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310169
  • ENSP00000312663
  • ENSG00000174343

Symbol
  • NACHRA9
  • NACHRA9
  • HSA243342
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
virus perturbation
0.72
cell type or tissue
0.66
phenotype
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.03   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
1
1
68
viral load
1
1
1
65.5
monocyte count
1
1
1
63.4
hemoglobin measurement
1
1
1
44.2
apolipoprotein B measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
1
68
viral load
1
65.5
monocyte count
1
63.4
hemoglobin measurement
1
44.2
apolipoprotein B measurement
1
39.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 9 subunit
VGNC:10795
471396
Macaque
cholinergic receptor nicotinic alpha 9 subunit
700612
Mouse
MGI:1202403
231252
Rat
RGD:621534
65024
Dog
cholinergic receptor nicotinic alpha 9 subunit
VGNC:39241
488832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 9 subunit
Macaque
cholinergic receptor nicotinic alpha 9 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 9 subunit
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Postsynaptic nicotinic acetylcholine receptors
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Postsynaptic nicotinic acetylcholine receptors
Protein-Protein Interactions (73)
1 – 10 of 73
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.999971987
p_ni:  0.000028006
p_wrong:  7e-9
Score:  0.156
Data Source:  BioPlex,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.99986651
p_ni:  0.000133489
Data Source:  BioPlex
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.999842011
p_ni:  0.000157988
p_wrong:  1e-9
Score:  0.284
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.999530412
p_ni:  0.000469588
Data Source:  BioPlex
TIMM29
Tdark
Novelty:  0.51321672
p_int:  0.999290992
p_ni:  0.000709008
Data Source:  BioPlex
DNAJC18
Tdark
Novelty:  1.38573997
p_int:  0.999206096
p_ni:  0.000793904
Score:  0.187
Data Source:  BioPlex,STRINGDB
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.998121542
p_ni:  0.001877843
p_wrong:  6.15e-7
Score:  0.387
Data Source:  BioPlex,STRINGDB
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.997996844
p_ni:  0.002003155
p_wrong:  1e-9
Data Source:  BioPlex
DNAJC30
Tdark
Novelty:  0.57178901
p_int:  0.997846479
p_ni:  0.002120823
p_wrong:  0.000032698
Data Source:  BioPlex
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.997826812
p_ni:  0.002173186
p_wrong:  2e-9
Score:  0.391
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.03

PubMed score by year
PubTator Score  10.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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