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Tbio
STAP2
Signal-transducing adaptor protein 2

Protein Summary
Description
Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000594605
  • ENSP00000471052
  • ENSG00000178078
  • ENST00000600324
  • ENSP00000468927

Symbol
  • BKS
  • BKS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
tissue sample
0.67
transcription factor
0.63
tissue
0.52
cellular component
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.46   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 238.46   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
1
2
72.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
72.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2147039
106766
Rat
RGD:1566020
363334
Dog
signal transducing adaptor family member 2
VGNC:46879
485041
Cow
signal transducing adaptor family member 2
VGNC:35359
505456
Opossum
signal transducing adaptor family member 2
100022851
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
signal transducing adaptor family member 2
Cow
signal transducing adaptor family member 2
Opossum
signal transducing adaptor family member 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
PTK6 Activates STAT3 (R-HSA-8849474)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Activates STAT3
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Activates STAT3
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (43)
1 – 10 of 43
PADI1
Tchem
Family: Enzyme
Novelty: 0.01388854
p_int: 0.999999972
p_ni: 2.8e-8
Score: 0.692
Data Source: BioPlex,STRINGDB
PTK6
Tchem
Family: Kinase
Novelty: 0.00480214
Score: 0.984
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.953
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.714
Data Source: STRINGDB
DOCK7
Tbio
Novelty: 0.03425586
Score: 0.71
Data Source: STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.692
Data Source: STRINGDB
LEPR
Tclin
Novelty: 0.00070587
Score: 0.67
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.664
Data Source: STRINGDB
HID1
Tdark
Novelty: 0.68399313
Score: 0.643
Data Source: STRINGDB
MARCH8
Tbio
Family: Enzyme
Novelty: 0.01492015
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  238.46

PubMed score by year
PubTator Score  6.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer