TUBGCP4
Gamma-tubulin complex component 4
Protein Summary
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
- ENST00000260383
- ENSP00000260383
- ENSG00000137822
- ENST00000564079
- ENSP00000456648
- 76P
- GCP4
- 76P
- GCP4
- GCP-4
- Grip76
- MCCRP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
kinase perturbation | 0.97 | ||
histone modification site profile | 0.92 | ||
transcription factor perturbation | 0.91 | ||
interacting protein | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.88 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 199 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.88 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 199 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0