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Tbio
TUBGCP4
Gamma-tubulin complex component 4

Protein Summary
Description
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260383
  • ENSP00000260383
  • ENSG00000137822
  • ENST00000564079
  • ENSP00000456648

Symbol
  • 76P
  • GCP4
  • 76P
  • GCP4
  • GCP-4
  • Grip76
  • MCCRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
histone modification site profile
0.92
transcription factor perturbation
0.91
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
M Phase
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (119)
1 – 10 of 119
TUBG2
Tbio
Novelty: 0.23300971
p_int: 0.999992732
p_ni: 0.000007261
p_wrong: 7e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
TUBGCP5
Tbio
Novelty: 0.12782794
p_int: 0.999991653
p_ni: 0.000008175
p_wrong: 1.72e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MZT2B
Tdark
Novelty: 4
p_int: 0.999979095
p_ni: 0.000020585
p_wrong: 3.2e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
TXNDC12
Tbio
Novelty: 0.02131718
p_int: 0.999948013
p_ni: 0.000051987
Score: 0.736
Data Source: BioPlex,STRINGDB
MZT1
Tdark
Novelty: 0.14016352
p_int: 0.999903982
p_ni: 0.000095682
p_wrong: 3.35e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty: 0.00116733
p_int: 0.999801541
p_ni: 0.000198459
Score: 0.188
Data Source: BioPlex,STRINGDB
TMEM9
Tbio
Novelty: 0.1192335
p_int: 0.99693663
p_ni: 0.003063364
p_wrong: 6e-9
Data Source: BioPlex
PRICKLE3
Tdark
Novelty: 0.43613707
p_int: 0.995950546
p_ni: 0.004049352
p_wrong: 1.02e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00748603
p_int: 0.991621852
p_ni: 0.008375861
p_wrong: 0.000002287
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00393331
p_int: 0.975701301
p_ni: 0.024289659
p_wrong: 0.00000904
Data Source: BioPlex
Publication Statistics
PubMed Score  82.61

PubMed score by year
PubTator Score  7.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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