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Tchem
PRKAG2
5'-AMP-activated protein kinase subunit gamma-2

Protein Summary
Description
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287878
  • ENSP00000287878
  • ENSG00000106617
  • ENST00000392801
  • ENSP00000376549
  • ENST00000418337
  • ENSP00000387386

Symbol
  • AAKG
  • CMH6
  • WPWS
  • AAKG2
  • H91620p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
1
molecular function
1
trait
0.99
transcription factor perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.81   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.81   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
12
9
10
2
99.4
creatinine measurement
5
6
8
99.1
hematocrit
6
4
6
98.7
hemoglobin measurement
4
4
4
98.7
serum urea measurement
2
5
5
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
10
2
99.4
creatinine measurement
8
99.1
hematocrit
6
98.7
hemoglobin measurement
4
98.7
serum urea measurement
5
98.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit gamma 2
VGNC:8739
463879
Mouse
MGI:1336153
108099
Dog
protein kinase AMP-activated non-catalytic subunit gamma 2
VGNC:44973
475546
Horse
protein kinase AMP-activated non-catalytic subunit gamma 2
VGNC:21840
100034098
Opossum
protein kinase AMP-activated non-catalytic subunit gamma 2
100018968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit gamma 2
Mouse
Dog
protein kinase AMP-activated non-catalytic subunit gamma 2
Horse
protein kinase AMP-activated non-catalytic subunit gamma 2
Opossum
protein kinase AMP-activated non-catalytic subunit gamma 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGJ0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (67)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (208)
1 – 10 of 208
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  1
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
p_int:  0.999997601
p_ni:  0.000002399
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999995732
p_ni:  0.000004268
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.999993833
p_ni:  0.000006167
Score:  0.813
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999692385
p_ni:  0.00021645
p_wrong:  0.000091165
Data Source:  BioPlex
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.999393335
p_ni:  0.000564567
p_wrong:  0.000042098
Score:  0.825
Data Source:  BioPlex,STRINGDB
GEMIN2
Tbio
Novelty:  0.02072868
p_int:  0.931386613
p_ni:  0.068602626
p_wrong:  0.000010762
Data Source:  BioPlex
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.833655496
p_ni:  0.000601443
p_wrong:  0.165743062
Score:  0.699
Data Source:  BioPlex,STRINGDB
NEFH
Tbio
Novelty:  0.0013027
p_int:  0.813579932
p_ni:  0.186403183
p_wrong:  0.000016886
Score:  0.163
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  139.81

PubMed score by year
PubTator Score  78.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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