You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRKAG3
5'-AMP-activated protein kinase subunit gamma-3

Protein Summary
Description
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233944
  • ENSP00000233944
  • ENSG00000115592
  • ENST00000439262
  • ENSP00000397133
  • ENST00000529249
  • ENSP00000436068

Symbol
  • AMPKG3
  • AMPKG3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
gene perturbation
0.71
biological process
0.66
pathway
0.51
disease
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.26   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.26   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
57
high density lipoprotein cholesterol measurement
3
1
4
46.5
triglyceride measurement
3
1
4
46.2
lymphocyte count
2
1
2
25.6
heel bone mineral density
1
1
1
24.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
57
high density lipoprotein cholesterol measurement
4
46.5
triglyceride measurement
4
46.2
lymphocyte count
2
25.6
heel bone mineral density
1
24.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1891343
241113
Dog
protein kinase AMP-activated non-catalytic subunit gamma 3
VGNC:44974
488526
Horse
protein kinase AMP-activated non-catalytic subunit gamma 3
VGNC:21841
100034099
Cow
protein kinase AMP-activated non-catalytic subunit gamma 3
VGNC:33323
511961
Opossum
protein kinase AMP-activated non-catalytic subunit gamma 3
100011008
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
protein kinase AMP-activated non-catalytic subunit gamma 3
Horse
protein kinase AMP-activated non-catalytic subunit gamma 3
Cow
protein kinase AMP-activated non-catalytic subunit gamma 3
Opossum
protein kinase AMP-activated non-catalytic subunit gamma 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGI9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (111)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Cellular responses to external stimuli
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (165)
1 – 10 of 165
PRKAB2
Tchem
Family: Enzyme
Novelty: 0.02815065
p_int: 0.999999238
p_ni: 7.62e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRKAB1
Tchem
Family: Kinase
Novelty: 0.01610606
p_int: 0.999997046
p_ni: 0.000002936
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01205826
p_int: 0.999955461
p_ni: 0.000044539
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family: Kinase
Novelty: 0.01795523
p_int: 0.999921676
p_ni: 0.000078324
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.991710628
p_ni: 0.008289371
p_wrong: 1e-9
Score: 0.195
Data Source: BioPlex,STRINGDB
PFDN1
Tbio
Novelty: 0.08811378
p_int: 0.83541467
p_ni: 0.16458533
Score: 0.214
Data Source: BioPlex,STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.951
Data Source: Reactome,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.944
Data Source: Reactome,STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.927
Data Source: Reactome,STRINGDB
RPTOR
Tbio
Novelty: 0.00119147
Score: 0.919
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  58.26

PubMed score by year
PubTator Score  17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: