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Tbio
TES
Testin

Protein Summary
Description
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358204
  • ENSP00000350937
  • ENSG00000135269
  • ENST00000393481
  • ENSP00000377121

Symbol
  • TESS
  • TESS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.93
PubMedID
0.85
transcription factor binding site profile
0.81
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.999993623
p_ni:  0.000006376
p_wrong:  1e-9
Data Source:  BioPlex
CTNNA1
Tbio
Novelty:  0.00925774
p_int:  0.99963929
p_ni:  0.00036071
Score:  0.233
Data Source:  BioPlex,STRINGDB
ZSCAN32
Tdark
Family:  TF
Novelty:  3.83392226
p_int:  0.999469222
p_ni:  0.000523323
p_wrong:  0.000007455
Score:  0.156
Data Source:  BioPlex,STRINGDB
KPTN
Tbio
Novelty:  0.06841936
p_int:  0.998945419
p_ni:  0.001053159
p_wrong:  0.000001422
Data Source:  BioPlex
SNN
Tdark
Novelty:  0.02279983
p_int:  0.997352366
p_ni:  0.002645344
p_wrong:  0.00000229
Score:  0.243
Data Source:  BioPlex,STRINGDB
TNFAIP8L2
Tbio
Novelty:  0.01938521
p_int:  0.99500459
p_ni:  0.004995409
p_wrong:  2e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.981969549
p_ni:  0.01802215
p_wrong:  0.0000083
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.962410963
p_ni:  0.03715816
p_wrong:  0.000430876
Data Source:  BioPlex
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
p_int:  0.956241064
p_ni:  0.043756013
p_wrong:  0.000002923
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZYX
Tbio
Novelty:  0.00375452
p_int:  0.943113757
p_ni:  0.037174108
p_wrong:  0.019712135
Score:  0.554
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
3
4
94.3
brain measurement
1
1
0
9.9
66.2
COVID-19
1
1
0
38.9
48
cortical thickness
1
1
0
6.3
30.9
cortical surface area measurement
1
1
0
6.3
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
94.3
brain measurement
0
9.9
66.2
COVID-19
0
38.9
48
cortical thickness
0
6.3
30.9
cortical surface area measurement
0
6.3
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
testin LIM domain protein
VGNC:4532
463669
Macaque
testin LIM domain protein
706879
Mouse
MGI:105081
21753
Rat
RGD:1566346
500040
Dog
testin LIM domain protein
VGNC:47256
475293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
testin LIM domain protein
Macaque
testin LIM domain protein
Mouse
Rat
Dog
testin LIM domain protein
Publication Statistics
PubMed Score 165.85
PubMed score by year
PubTator Score 80.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title