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Tbio
TES
Testin

Protein Summary
Description
Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358204
  • ENSP00000350937
  • ENSG00000135269
  • ENST00000393481
  • ENSP00000377121

Symbol
  • TESS
  • TESS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.93
PubMedID
0.85
transcription factor binding site profile
0.81
microRNA
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1201.85   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1201.85   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (72)
1 – 10 of 72
GORASP1
Tbio
Novelty: 0.0271696
p_int: 0.999993623
p_ni: 0.000006376
p_wrong: 1e-9
Data Source: BioPlex
CTNNA1
Tbio
Novelty: 0.0104485
p_int: 0.99963929
p_ni: 0.00036071
Score: 0.233
Data Source: BioPlex,STRINGDB
ZSCAN32
Tdark
Family: TF
Novelty: 0.60869565
p_int: 0.999469222
p_ni: 0.000523323
p_wrong: 0.000007455
Score: 0.156
Data Source: BioPlex,STRINGDB
KPTN
Tbio
Novelty: 0.03538431
p_int: 0.998945419
p_ni: 0.001053159
p_wrong: 0.000001422
Data Source: BioPlex
SNN
Tdark
Novelty: 0.00425238
p_int: 0.997352366
p_ni: 0.002645344
p_wrong: 0.00000229
Score: 0.243
Data Source: BioPlex,STRINGDB
TNFAIP8L2
Tbio
Novelty: 0.0189457
p_int: 0.99500459
p_ni: 0.004995409
p_wrong: 2e-9
Score: 0.513
Data Source: BioPlex,STRINGDB
NECAP2
Tdark
Novelty: 0.58353317
p_int: 0.981969549
p_ni: 0.01802215
p_wrong: 0.0000083
Score: 0.187
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
p_int: 0.962410963
p_ni: 0.03715816
p_wrong: 0.000430876
Data Source: BioPlex
RNF135
Tbio
Family: Enzyme
Novelty: 0.0446139
p_int: 0.956241064
p_ni: 0.043756013
p_wrong: 0.000002923
Score: 0.173
Data Source: BioPlex,STRINGDB
ZYX
Tbio
Novelty: 0.00647259
p_int: 0.943113757
p_ni: 0.037174108
p_wrong: 0.019712135
Score: 0.554
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1201.85

PubMed score by year
PubTator Score  80.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer