Tchem KCNN3 Small conductance calcium-activated potassium channel protein 3

Protein Summary

Description

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9UGI6
• B1ANX0
• O43517
• Q86VF9
• Q8WXG7
• SK3

Gene Name

• KCNN3

Ensembl ID

• ENST00000358505
• ENSP00000351295
• ENSG00000143603
• ENST00000361147
• ENSP00000354764

Symbol

• K3
• SK3
• hSK3
• SKCA3
• KCa2.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.86
molecular function	0.84
transcription factor	0.78
trait	0.75
gene perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Potassium Channel / Small Conductance Calcium-activated Potassium Channel Protein 3

Protein / Transporter / Ion Channel / Potassium Channel / Voltage-gated Potassium Channel / Small Conductance Calcium-activated Potassium Channel Protein 3

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Small Conductance Calcium-activated Potassium Channel Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.41   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.41   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2