KCNN3
Small conductance calcium-activated potassium channel protein 3
Protein Classes
Protein Summary
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could ...more
- ENST00000358505
- ENSP00000351295
- ENSG00000143603
- ENST00000361147
- ENSP00000354764
- K3
- SK3
- hSK3
- SKCA3
- KCa2.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.86 | ||
molecular function | 0.84 | ||
transcription factor | 0.78 | ||
trait | 0.75 | ||
gene perturbation | 0.72 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 428.7 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 428.7 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 30
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (30)
1 – 10 of 30
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
9 | 7 | 0 | 1.1 | 99.8 | |||||
interleukin 6 receptor subunit alpha measurement | 1 | 1 | 1 | 67.9 | |||||
birth weight | 2 | 1 | 2 | 41.5 | |||||
prostate carcinoma | 2 | 1 | 0 | 1.1 | 29.7 | ||||
appendicular lean mass | 1 | 1 | 1 | 21.3 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 99.8 | |||||
interleukin 6 receptor subunit alpha measurement | 1 | 67.9 | |||||
birth weight | 2 | 41.5 | |||||
prostate carcinoma | 0 | 1.1 | 29.7 | ||||
appendicular lean mass | 1 | 21.3 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 3 | VGNC:10679 | 739670 | |||||
Macaque | potassium calcium-activated channel subfamily N member 3 | 574397 | ||||||
Mouse | MGI:2153183 | 140493 | ||||||
Rat | RGD:2964 | 54263 | ||||||
Dog | potassium calcium-activated channel subfamily N member 3 | VGNC:42286 | 490441 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 3 | |||||
Macaque | potassium calcium-activated channel subfamily N member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium calcium-activated channel subfamily N member 3 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ca2+ activated K+ channels | ||||
Reactome | Neuronal System | ||||
Reactome | Potassium Channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ca2+ activated K+ channels | ||||
Neuronal System | ||||
Potassium Channels | ||||
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (89)
1 – 10 of 89
KCNMB4
Family: IC
Novelty: 0.05362954
Score: 0.959
Data Source: STRINGDB
KCNMA1
Family: IC
Novelty: 0.00088182
Score: 0.946
Data Source: STRINGDB
KCNU1
Family: IC
Novelty: 0.02284336
Score: 0.887
Data Source: STRINGDB
CALM1
Novelty: 0.00308267
Score: 0.858
Data Source: STRINGDB
KCNMB1
Family: IC
Novelty: 0.00736653
Score: 0.853
Data Source: STRINGDB
KCNMB3
Family: IC
Novelty: 0.08717845
Score: 0.846
Data Source: STRINGDB
KCNMB2
Family: IC
Novelty: 0.4425394
Score: 0.817
Data Source: STRINGDB
KCNN4
Family: IC
Novelty: 0.00244935
Score: 0.815
Data Source: STRINGDB
KCNN1
Family: IC
Novelty: 0.04266994
Score: 0.81
Data Source: Reactome,STRINGDB
KCNN2
Family: IC
Novelty: 0.01865346
Score: 0.807
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 428.70
PubMed score by year
PubTator Score 154.11
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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