KCNN3
Small conductance calcium-activated potassium channel protein 3
Protein Summary
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could ...more
- ENST00000358505
- ENSP00000351295
- ENSG00000143603
- ENST00000361147
- ENSP00000354764
- K3
- SK3
- hSK3
- SKCA3
- KCa2.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.86 | ||
molecular function | 0.84 | ||
transcription factor | 0.78 | ||
trait | 0.75 | ||
gene perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 434.9 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 434.9 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 30
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (30)
Protein-Protein Interactions (89)
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ca2+ activated K+ channels | ||||
Reactome | Neuronal System | ||||
Reactome | Potassium Channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ca2+ activated K+ channels | ||||
Neuronal System | ||||
Potassium Channels | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
9 | 7 | 0 | 1.1 | 98.8 | |||||
C-reactive protein measurement | 2 | 7 | 7 | 97.2 | |||||
sex hormone-binding globulin measurement | 6 | 3 | 6 | 96 | |||||
eosinophil count | 2 | 1 | 2 | 84.6 | |||||
interleukin 6 receptor subunit alpha measurement | 1 | 1 | 1 | 71.6 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 98.8 | |||||
C-reactive protein measurement | 7 | 97.2 | |||||
sex hormone-binding globulin measurement | 6 | 96 | |||||
eosinophil count | 2 | 84.6 | |||||
interleukin 6 receptor subunit alpha measurement | 1 | 71.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 3 | VGNC:10679 | 739670 | |||||
Macaque | potassium calcium-activated channel subfamily N member 3 | 574397 | ||||||
Mouse | MGI:2153183 | 140493 | ||||||
Rat | RGD:2964 | 54263 | ||||||
Dog | potassium calcium-activated channel subfamily N member 3 | VGNC:42286 | 490441 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 3 | |||||
Macaque | potassium calcium-activated channel subfamily N member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium calcium-activated channel subfamily N member 3 | |||||
Publication Statistics
PubMed Score 434.90
PubMed score by year
PubTator Score 154.11
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (83)
GeneRif Annotations (59)
Items per page:
0 of 0
PMID | Year | Title |
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