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Tchem
KCNN3
Small conductance calcium-activated potassium channel protein 3

Protein Classes
Protein Summary
Description
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358505
  • ENSP00000351295
  • ENSG00000143603
  • ENST00000361147
  • ENSP00000354764

Symbol
  • K3
  • SK3
  • hSK3
  • SKCA3
  • KCa2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.86
molecular function
0.84
transcription factor
0.78
trait
0.75
gene perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.7   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 428.7   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
7
0
1.1
99.8
interleukin 6 receptor subunit alpha measurement
1
1
1
67.9
birth weight
2
1
2
41.5
prostate carcinoma
2
1
0
1.1
29.7
appendicular lean mass
1
1
1
21.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
99.8
interleukin 6 receptor subunit alpha measurement
1
67.9
birth weight
2
41.5
prostate carcinoma
0
1.1
29.7
appendicular lean mass
1
21.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 3
VGNC:10679
739670
Macaque
potassium calcium-activated channel subfamily N member 3
574397
Mouse
MGI:2153183
140493
Rat
RGD:2964
54263
Dog
potassium calcium-activated channel subfamily N member 3
VGNC:42286
490441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily N member 3
Macaque
potassium calcium-activated channel subfamily N member 3
Mouse
Rat
Dog
potassium calcium-activated channel subfamily N member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UGI6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Neuronal System
Potassium Channels
Protein-Protein Interactions (89)
1 – 10 of 89
KCNMB4
Tbio
Family: IC
Novelty: 0.05362954
Score: 0.959
Data Source: STRINGDB
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.946
Data Source: STRINGDB
KCNU1
Tbio
Family: IC
Novelty: 0.02284336
Score: 0.887
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.858
Data Source: STRINGDB
KCNMB1
Tbio
Family: IC
Novelty: 0.00736653
Score: 0.853
Data Source: STRINGDB
KCNMB3
Tbio
Family: IC
Novelty: 0.08717845
Score: 0.846
Data Source: STRINGDB
KCNMB2
Tbio
Family: IC
Novelty: 0.4425394
Score: 0.817
Data Source: STRINGDB
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.815
Data Source: STRINGDB
KCNN1
Tchem
Family: IC
Novelty: 0.04266994
Score: 0.81
Data Source: Reactome,STRINGDB
KCNN2
Tchem
Family: IC
Novelty: 0.01865346
Score: 0.807
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  428.70

PubMed score by year
PubTator Score  154.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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