Tbio ZRANB1 Ubiquitin thioesterase ZRANB1

Protein Summary

Description

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.

Uniprot Accession IDs

• Q9UGI0
• B4DZ98
• D3DRF4
• Q5SQP6
• Q69YK3

Gene Name

• ZRANB1

Ensembl ID

• ENST00000359653
• ENSP00000352676
• ENSG00000019995

Symbol

• TRABID
• TRABID

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
molecular function	0.7
microRNA	0.67
kinase perturbation	0.66
transcription factor	0.6

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Ubiquitin Thioesterase Zranb1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Thioesterase Zranb1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.98   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.98   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0