ZRANB1
Ubiquitin thioesterase ZRANB1
Protein Summary
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
- ENST00000359653
- ENSP00000352676
- ENSG00000019995
- TRABID
- TRABID
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
molecular function | 0.7 | ||
microRNA | 0.67 | ||
kinase perturbation | 0.66 | ||
transcription factor | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.52 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.52 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (74)
PBLD
Novelty: 0.09777309
p_int: 0.999999462
p_ni: 1.21e-7
p_wrong: 4.17e-7
Score: 0.54
Data Source: BioPlex,STRINGDB
TMEM31
Novelty: 0.65381391
p_int: 0.999998043
p_ni: 8.51e-7
p_wrong: 0.000001106
Data Source: BioPlex
ZNF414
Novelty: 1.29024829
p_int: 0.999997125
p_ni: 0.000002462
p_wrong: 4.12e-7
Score: 0.206
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Ovarian tumor domain proteases | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Metabolism of proteins | ||||
Ovarian tumor domain proteases | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (5)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 4 | 3 | 4 | 80.3 | |||||
body height | 2 | 2 | 2 | 74.5 | |||||
red blood cell density measurement | 1 | 1 | 1 | 57.3 | |||||
1 | 1 | 0 | 1.1 | 49.5 | |||||
physical activity measurement | 1 | 1 | 0 | 1.1 | 40.7 | ||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 4 | 80.3 | |||||
body height | 2 | 74.5 | |||||
red blood cell density measurement | 1 | 57.3 | |||||
0 | 1.1 | 49.5 | |||||
physical activity measurement | 0 | 1.1 | 40.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger RANBP2-type containing 1 | VGNC:7880 | 450809 | |||||
Macaque | zinc finger RANBP2-type containing 1 | 697541 | ||||||
Mouse | MGI:106441 | 360216 | ||||||
Rat | RGD:2321751 | 100360606 | ||||||
Dog | zinc finger RANBP2-type containing 1 | VGNC:48847 | 486931 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger RANBP2-type containing 1 | |||||
Macaque | zinc finger RANBP2-type containing 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger RANBP2-type containing 1 | |||||
Publication Statistics
PubMed Score 13.52
PubMed score by year
PubTator Score 5.50
PubTator score by year
Related Publications
Text Mined References (11)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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