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Tbio
ZRANB1
Ubiquitin thioesterase ZRANB1

Protein Summary
Description
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359653
  • ENSP00000352676
  • ENSG00000019995

Symbol
  • TRABID
  • TRABID
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
molecular function
0.7
microRNA
0.67
kinase perturbation
0.66
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
59.8
blood urea nitrogen measurement
1
1
1
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
59.8
blood urea nitrogen measurement
1
14.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 1
VGNC:7880
450809
Macaque
zinc finger RANBP2-type containing 1
697541
Mouse
MGI:106441
360216
Rat
RGD:2321751
100360606
Dog
zinc finger RANBP2-type containing 1
VGNC:48847
486931
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger RANBP2-type containing 1
Macaque
zinc finger RANBP2-type containing 1
Mouse
Rat
Dog
zinc finger RANBP2-type containing 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (74)
1 – 10 of 74
PBLD
Tbio
Novelty: 0.09777309
p_int: 0.999999462
p_ni: 1.21e-7
p_wrong: 4.17e-7
Score: 0.54
Data Source: BioPlex,STRINGDB
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.999998043
p_ni: 8.51e-7
p_wrong: 0.000001106
Data Source: BioPlex
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.999997125
p_ni: 0.000002462
p_wrong: 4.12e-7
Score: 0.206
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.979
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.97
Data Source: Reactome,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.968
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.962
Data Source: STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.948
Data Source: Reactome,STRINGDB
OTUD7B
Tbio
Novelty: 0.0136028
Score: 0.936
Data Source: STRINGDB
TNFAIP3
Tbio
Novelty: 0.00257088
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.48

PubMed score by year
PubTator Score  5.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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