Tbio ZRANB1 Ubiquitin thioesterase ZRANB1

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Ubiquitin Thioesterase Zranb1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Ubiquitin Thioesterase Zranb1

Protein Summary

Description

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling.

Uniprot Accession IDs

• Q9UGI0
• B4DZ98
• D3DRF4
• Q5SQP6
• Q69YK3

Gene Name

• ZRANB1

Ensembl ID

• ENST00000359653
• ENSP00000352676
• ENSG00000019995

Symbol

• TRABID
• TRABID

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
molecular function	0.7
microRNA	0.67
kinase perturbation	0.66
transcription factor	0.6

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.48   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1	1	1		59.8
blood urea nitrogen measurement	EFO_0004741	1	1	1		14.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell density measurement	EFO_0007978	1		59.8
blood urea nitrogen measurement	EFO_0004741	1		14.5

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Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger RANBP2-type containing 1	VGNC:7880	450809
Macaque	zinc finger RANBP2-type containing 1		697541
Mouse	zinc finger, RAN-binding domain containing 1	MGI:106441	360216
Rat	zinc finger RANBP2-type containing 1	RGD:2321751	100360606
Dog	zinc finger RANBP2-type containing 1	VGNC:48847	486931

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger RANBP2-type containing 1
Macaque	zinc finger RANBP2-type containing 1
Mouse	zinc finger, RAN-binding domain containing 1
Rat	zinc finger RANBP2-type containing 1
Dog	zinc finger RANBP2-type containing 1

Protein Structure (2 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (4)

Reactome (4)

Deubiquitination (R-HSA-5688426)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deubiquitination	278 targets	R-HSA-5688426
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Ovarian tumor domain proteases	38 targets	R-HSA-5689896
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Deubiquitination	278 targets	R-HSA-5688426
Metabolism of proteins	2050 targets	R-HSA-392499
Ovarian tumor domain proteases	38 targets	R-HSA-5689896
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (19)

Functions (4)

Components (5)

Processes (10)

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GO Term	Evidence	Assigned by
K63-linked polyubiquitin modification-dependent protein binding	Inferred from Direct Assay (IDA)	BHF-UCL
thiol-dependent ubiquitin-specific protease activity	Inferred from Direct Assay (IDA)	UniProtKB
thiol-dependent ubiquitinyl hydrolase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (74)

Explore Interacting Targets

1 – 10 of 74

• See Interactions on String-DB

PBLD

Tbio

Novelty: 0.09777309

p_int: 0.999999462

p_ni: 1.21e-7

p_wrong: 4.17e-7

Score: 0.54

Data Source: BioPlex,STRINGDB

TMEM31

Tdark

Novelty: 0.65381391

p_int: 0.999998043

p_ni: 8.51e-7

p_wrong: 0.000001106

Data Source: BioPlex

ZNF414

Tdark

Novelty: 1.29024829

p_int: 0.999997125

p_ni: 0.000002462

p_wrong: 4.12e-7

Score: 0.206

Data Source: BioPlex,STRINGDB

UBC

Tbio

Novelty: 0.00204643

Score: 0.979

Data Source: STRINGDB

TRAF6

Tbio

Novelty: 0.00109366

Score: 0.97

Data Source: Reactome,STRINGDB

UBA52

Tbio

Novelty: 0.01637744

Score: 0.968

Data Source: STRINGDB

UBB

Tbio

Novelty: 0.00661254

Score: 0.962

Data Source: STRINGDB

APC

Tbio

Novelty: 0.00168376

Score: 0.948

Data Source: Reactome,STRINGDB

OTUD7B

Tbio

Novelty: 0.0136028

Score: 0.936

Data Source: STRINGDB

TNFAIP3

Tbio

Novelty: 0.00257088

Score: 0.924

Data Source: STRINGDB

Publication Statistics

PubMed Score  13.48

PubMed score by year

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PubTator Score  5.5

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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ANK repeat
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Hydrolase
Metal-binding
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Protease
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Repeat

GWAS Trait Find Similar Targets

blood urea nitrogen measurement
red blood cell density measurement

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging