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Tbio
MTRF1L
Peptide chain release factor 1-like, mitochondrial

Protein Summary
Description
Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367230
  • ENSP00000356199
  • ENSG00000112031
  • ENST00000367231
  • ENSP00000356200
  • ENST00000367233
  • ENSP00000356202

Symbol
  • MTRF1A
  • MRF1L
  • HMRF1L
  • mtRF1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor binding site profile
0.84
histone modification site profile
0.82
virus perturbation
0.64
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.5   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1.1
92.8
neutrophil count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
92.8
neutrophil count
1
10.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translational release factor 1 like
VGNC:3501
463084
Macaque
mitochondrial translational release factor 1 like
703103
Mouse
MGI:1918830
108853
Rat
RGD:1598312
361473
Dog
mitochondrial translational release factor 1 like
VGNC:53739
484040
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial translational release factor 1 like
Macaque
mitochondrial translational release factor 1 like
Mouse
Rat
Dog
mitochondrial translational release factor 1 like
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation termination
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation termination
Translation
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (200)
1 – 10 of 200
HEMK1
Tbio
Family: Enzyme
Novelty: 0.03509926
p_int: 0.998980971
p_ni: 0.000250793
p_wrong: 0.000768236
Score: 0.847
Data Source: BioPlex,STRINGDB
CHI3L1
Tbio
Family: Enzyme
Novelty: 0.00119387
p_int: 0.991706425
p_ni: 0.008293437
p_wrong: 1.38e-7
Score: 0.461
Data Source: BioPlex,STRINGDB
ACAD9
Tbio
Family: Enzyme
Novelty: 0.03238308
p_int: 0.991372327
p_ni: 0.008627673
Score: 0.208
Data Source: BioPlex,STRINGDB
MRPL58
Tbio
Family: Enzyme
Novelty: 0.00178011
Score: 0.988
Data Source: STRINGDB
MRPS7
Tbio
Novelty: 0.00153134
Score: 0.981
Data Source: STRINGDB
MRPS16
Tbio
Novelty: 0.24108603
Score: 0.979
Data Source: STRINGDB
MRPL20
Tdark
Novelty: 0.91178993
Score: 0.977
Data Source: STRINGDB
MRRF
Tbio
Novelty: 0.00269663
Score: 0.977
Data Source: STRINGDB
MRPL17
Tdark
Novelty: 1.20541719
Score: 0.976
Data Source: STRINGDB
MRPL27
Tbio
Novelty: 0.15636105
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.50

PubMed score by year
PubTator Score  7.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer