Tbio MTRF1L Peptide chain release factor 1-like, mitochondrial

Protein Summary

Description

Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9UGC7
• B3KTA0
• Q3KR06
• Q5TF44
• Q5TF50
• Q96CC5
• Q96EX4
• Q96K40

Gene Name

• MTRF1L

Ensembl ID

• ENST00000367230
• ENSP00000356199
• ENSG00000112031
• ENST00000367231
• ENSP00000356200
• ENST00000367233
• ENSP00000356202

Symbol

• MTRF1A
• MRF1L
• HMRF1L
• mtRF1a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor binding site profile	0.84
histone modification site profile	0.82
virus perturbation	0.64
tissue sample	0.61

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Release Factor / Peptide Chain Release Factor 1-like, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Release Factor / Peptide Chain Release Factor 1-like, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 168   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.81   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0