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Tbio
RGS17
Regulator of G-protein signaling 17

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206262
  • ENSP00000206262
  • ENSG00000091844
  • ENST00000367225
  • ENSP00000356194

Symbol
  • RGSZ2
  • RGSZ2
  • RGS-17
  • hRGS17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.69
PubMedID
0.58
disease
0.57
cell type or tissue
0.54
kinase perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.67   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.67   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
94.6
body mass index
4
4
5
94.1
2
2
2
91
high density lipoprotein cholesterol measurement
3
3
3
87.4
self reported educational attainment
1
1
1
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
94.6
body mass index
5
94.1
2
91
high density lipoprotein cholesterol measurement
3
87.4
self reported educational attainment
1
79.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 17
VGNC:11204
737204
Macaque
regulator of G protein signaling 17
100429275
Mouse
MGI:1927469
56533
Rat
RGD:1305515
308118
Dog
regulator of G protein signaling 17
VGNC:45526
608867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 17
Macaque
regulator of G protein signaling 17
Mouse
Rat
Dog
regulator of G protein signaling 17
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UGC6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
G alpha (z) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
G alpha (z) signalling events
GPCR downstream signalling
Signal Transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (16)
1 – 10 of 16
GNAZ
Tbio
Novelty: 0.02008523
Score: 0.93
Data Source: Reactome,STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.685
Data Source: STRINGDB
KCNJ9
Tbio
Family: IC
Novelty: 0.02279401
Score: 0.634
Data Source: STRINGDB
RGS7BP
Tbio
Novelty: 0.05820527
Score: 0.598
Data Source: STRINGDB
HINT1
Tbio
Novelty: 0.00815168
Score: 0.574
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.561
Data Source: STRINGDB
ARHGEF1
Tbio
Novelty: 0.00677208
Score: 0.529
Data Source: STRINGDB
PPP1R14C
Tbio
Family: Enzyme
Novelty: 0.04635786
Score: 0.522
Data Source: STRINGDB
OPRL1
Tchem
Family: GPCR
Novelty: 0.00186729
Score: 0.512
Data Source: STRINGDB
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
Score: 0.509
Data Source: STRINGDB
Publication Statistics
PubMed Score  29.67

PubMed score by year
PubTator Score  17.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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