Tbio ABCF2 ATP-binding cassette sub-family F member 2

Protein Summary

Description

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Mar 2019]

Uniprot Accession IDs

• Q9UG63
• O60864
• Q75MJ0
• Q75MJ1
• Q96TE8

Gene Name

• ABCF2

Ensembl ID

• ENST00000287844
• ENSP00000287844
• ENSG00000033050

Symbol

• ABC28
• HUSSY18
• HUSSY-18
• EST133090

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
transcription factor perturbation	0.88
transcription factor binding site profile	0.84
kinase perturbation	0.81
disease perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family F Member 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Atp-binding Cassette Sub-family F Member 2

Protein / Hydrolase / Atp-binding Cassette Sub-family F Member 2

DTO Classes

Protein / Enzyme / Hydrolase / Atp-binding Cassette Sub-family F Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.08   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 311   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.08   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0