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Tbio
ABCF2
ATP-binding cassette sub-family F member 2

Protein Summary
Description
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, Mar 2019]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287844
  • ENSP00000287844
  • ENSG00000033050

Symbol
  • ABC28
  • HUSSY18
  • HUSSY-18
  • EST133090
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
transcription factor perturbation
0.88
transcription factor binding site profile
0.84
kinase perturbation
0.81
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
1
1
84.1
femoral neck bone mineral density
1
1
1
36.2
body height
1
1
1
19.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
1
84.1
femoral neck bone mineral density
1
36.2
body height
1
19.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1351657
27407
Horse
ATP binding cassette subfamily F member 2
VGNC:14928
100063507
Cow
ATP binding cassette subfamily F member 2
VGNC:25481
513061
Opossum
ATP binding cassette subfamily F member 2
100015529
Zebrafish
ZDB-GENE-030131-8714
336770
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
ATP binding cassette subfamily F member 2
Cow
ATP binding cassette subfamily F member 2
Opossum
ATP binding cassette subfamily F member 2
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UG63-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (98)
1 – 10 of 98
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.999969714
p_ni: 0.000030286
Score: 0.276
Data Source: BioPlex,STRINGDB
GNL1
Tbio
Novelty: 0.02864525
p_int: 0.998567852
p_ni: 0.001432145
p_wrong: 3e-9
Score: 0.543
Data Source: BioPlex,STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
p_int: 0.988807309
p_ni: 0.011192691
Score: 0.27
Data Source: BioPlex,STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.987253326
p_ni: 0.012746674
Score: 0.619
Data Source: BioPlex,STRINGDB
NUDCD1
Tbio
Novelty: 0.07471096
p_int: 0.985216463
p_ni: 0.014783537
Score: 0.345
Data Source: BioPlex,STRINGDB
ABCE1
Tbio
Family: Transporter
Novelty: 0.00529126
Score: 0.952
Data Source: STRINGDB
ACAD9
Tbio
Family: Enzyme
Novelty: 0.03238308
Score: 0.79
Data Source: STRINGDB
ABCB6
Tbio
Family: Transporter
Novelty: 0.00552057
Score: 0.788
Data Source: STRINGDB
ABCB1
Tchem
Family: Transporter
Novelty: 0.00018144
Score: 0.775
Data Source: STRINGDB
PSME3
Tbio
Novelty: 0.01051254
Score: 0.757
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.90

PubMed score by year
PubTator Score  9.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer