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Tbio
PISD
Phosphatidylserine decarboxylase proenzyme, mitochondrial

Protein Summary
Description
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266095
  • ENSP00000266095
  • ENSG00000241878
  • ENST00000382151
  • ENSP00000371586
  • ENST00000439502
  • ENSP00000391739

Symbol
  • PSD
  • PSDC
  • PSSC
  • DJ858B16
  • dJ858B16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
metabolite
0.88
transcription factor binding site profile
0.85
transcription factor perturbation
0.8
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.42   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.42   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
45.7
neutrophil percentage of leukocytes
1
1
1
38.8
waist circumference
1
1
1
31.4
1
1
0
1.1
30.2
diet measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
45.7
neutrophil percentage of leukocytes
1
38.8
waist circumference
1
31.4
0
1.1
30.2
diet measurement
1
17.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylserine decarboxylase
VGNC:5297
107970227
Macaque
phosphatidylserine decarboxylase
716905
Mouse
MGI:5313118
Rat
RGD:1596729
681361
Dog
phosphatidylserine decarboxylase
VGNC:44581
477544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylserine decarboxylase
Macaque
phosphatidylserine decarboxylase
Mouse
Rat
Dog
phosphatidylserine decarboxylase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UG56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PE
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PE
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (118)
1 – 10 of 118
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.986
Data Source:  STRINGDB
PTDSS1
Tbio
Family:  Enzyme
Novelty:  0.01932442
Score:  0.978
Data Source:  STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.974
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.972
Data Source:  STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.967
Data Source:  STRINGDB
MBOAT1
Tdark
Family:  Enzyme
Novelty:  0.05745641
Score:  0.964
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.96
Data Source:  STRINGDB
PTDSS2
Tbio
Family:  Enzyme
Novelty:  0.08551192
Score:  0.96
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.935
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  101.42

PubMed score by year
PubTator Score  20.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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