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Tbio
IFT172
Intraflagellar transport protein 172 homolog

Protein Classes
Protein Summary
Description
Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). This gene encodes a subunit of the intraflagellar transport subcomplex IFT-B. Subcomplexes IFT-A and IFT-B are necessary for ciliary assembly and maintenance. Mutations in this gene have been associated with skeletal ciliopathies, with or without polydactyly, such as such short-rib thoracic dysplasias 1, 9 or 10. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260570
  • ENSP00000260570
  • ENSG00000138002
  • ENST00000359466
  • ENSP00000352443

Symbol
  • KIAA1179
  • SLB
  • wim
  • RP71
  • BBS20
  • osm-1
  • NPHP17
  • SRTD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.85
kinase perturbation
0.84
disease perturbation
0.74
cell line
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.76   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.76   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (119)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
35
26
67
5.2
100
total cholesterol measurement
12
10
19
3.8
99.6
C-reactive protein measurement
8
6
13
99.3
serum gamma-glutamyl transferase measurement
6
6
9
3.2
99.2
apolipoprotein B measurement
2
5
5
98.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
67
5.2
100
total cholesterol measurement
19
3.8
99.6
C-reactive protein measurement
13
99.3
serum gamma-glutamyl transferase measurement
9
3.2
99.2
apolipoprotein B measurement
5
98.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 172
VGNC:272
459104
Macaque
intraflagellar transport 172
700948
Mouse
MGI:2682064
67661
Dog
intraflagellar transport 172
VGNC:41884
483013
Horse
intraflagellar transport 172
VGNC:18960
100055101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 172
Macaque
intraflagellar transport 172
Mouse
Dog
intraflagellar transport 172
Horse
intraflagellar transport 172
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UG01-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Gene Ontology Terms (29)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (130)
1 – 10 of 130
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999998446
p_ni:  0.000001554
Score:  0.997
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999987474
p_ni:  0.000012526
Score:  0.982
Data Source:  BioPlex,STRINGDB
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999984727
p_ni:  0.000015273
Score:  0.973
Data Source:  BioPlex,STRINGDB
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.999963621
p_ni:  0.000036378
p_wrong:  1e-9
Score:  0.985
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999952847
p_ni:  0.000047153
Data Source:  BioPlex
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999761831
p_ni:  0.000238169
Score:  0.987
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.998697999
p_ni:  0.001302001
Score:  0.687
Data Source:  BioPlex,STRINGDB
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.990528821
p_ni:  0.009471179
Score:  0.232
Data Source:  BioPlex,STRINGDB
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.983056173
p_ni:  0.016943827
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.941903984
p_ni:  0.058096016
Score:  0.155
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  89.76

PubMed score by year
PubTator Score  24.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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