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Tbio
CNOT8
CCR4-NOT transcription complex subunit 8

Protein Summary
Description
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285896
  • ENSP00000285896
  • ENSG00000155508
  • ENST00000403027
  • ENSP00000384747
  • ENST00000517876
  • ENSP00000430493
  • ENST00000519404
  • ENSP00000430833
  • ENST00000520671
  • ENSP00000428305
  • ENST00000521450
  • ENSP00000431034
  • ENST00000521583
  • ENSP00000429882
  • ENST00000523698
  • ENSP00000428565

Symbol
  • CALIF
  • POP2
  • CAF1
  • POP2
  • CALIF
  • Caf1b
  • hCAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor binding site profile
0.93
kinase perturbation
0.91
transcription factor perturbation
0.91
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.13   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.13   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0