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Tdark
DNAJC5B
DnaJ homolog subfamily C member 5B

Protein Summary
Description
This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins that is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. The encoded protein, together with heat shock protein 70, is thought to regulate the proper folding of other proteins. The orthologous mouse protein is membrane-associated and is targeted to the trans-golgi network. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276570
  • ENSP00000276570
  • ENSG00000147570

Symbol
  • CSP-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.71
cell line
0.59
cell type or tissue
0.54
transcription factor
0.54
tissue
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.99   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
70.8
eosinophil count
2
2
2
67.6
mean corpuscular hemoglobin concentration
1
1
1
24.3
platelet crit
1
1
1
24.2
eosinophil percentage of leukocytes
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
70.8
eosinophil count
2
67.6
mean corpuscular hemoglobin concentration
1
24.3
platelet crit
1
24.2
eosinophil percentage of leukocytes
1
12.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C5 beta
VGNC:13168
744068
Macaque
DnaJ heat shock protein family (Hsp40) member C5 beta
702408
Mouse
MGI:1913576
66326
Rat
RGD:1562486
499579
Dog
DnaJ heat shock protein family (Hsp40) member C5 beta
VGNC:53546
610015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C5 beta
Macaque
DnaJ heat shock protein family (Hsp40) member C5 beta
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C5 beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UF47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (59)
1 – 10 of 59
SGTA
Tbio
Novelty:  0.01488022
Score:  0.753
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.752
Data Source:  STRINGDB
HSPA1L
Tbio
Novelty:  0.01658161
Score:  0.743
Data Source:  STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
Score:  0.742
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.741
Data Source:  STRINGDB
HSPA1B
Tbio
Novelty:  0.01429214
Score:  0.737
Data Source:  STRINGDB
HSPA6
Tbio
Novelty:  0.00654285
Score:  0.735
Data Source:  STRINGDB
RNF219
Tdark
Novelty:  0.26163921
Score:  0.733
Data Source:  STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
Score:  0.689
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.684
Data Source:  STRINGDB
Publication Statistics
PubMed Score  4.99

PubMed score by year
PubTator Score  3.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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