Tdark CACNG5 Voltage-dependent calcium channel gamma-5 subunit

Protein Summary

Description

Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9UF02
• A8K2A6
• Q547R3
• Q8WXS7
• Q9UHM3

Gene Name

• CACNG5

Ensembl ID

• ENST00000307139
• ENSP00000303092
• ENSG00000075429
• ENST00000533854
• ENSP00000436836

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
cell type or tissue	0.62
cell line	0.53
metabolite	0.45
chemical	0.42

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Channel Auxiliary Subunit 1-8 (Cca) Family / Voltage-dependent Calcium Channel Gamma-5 Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.74   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0