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Tbio
ADD3
Gamma-adducin

Protein Summary
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277900
  • ENSP00000277900
  • ENSG00000148700
  • ENST00000356080
  • ENSP00000348381
  • ENST00000360162
  • ENSP00000353286

Symbol
  • ADDL
  • ADDL
  • CPSQ3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.97
transcription factor
0.86
small molecule perturbation
0.8
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.19   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (58)
1 – 10 of 58
ANKRD29
Tdark
Novelty: 6
p_int: 0.999999938
p_ni: 6.2e-8
Score: 0.686
Data Source: BioPlex,STRINGDB
GBP2
Tbio
Novelty: 0.02823155
p_int: 0.999998765
p_ni: 0.000001235
Score: 0.189
Data Source: BioPlex,STRINGDB
ADD2
Tbio
Family: Enzyme
Novelty: 0.00893667
p_int: 0.999943751
p_ni: 0.000056249
Score: 0.659
Data Source: BioPlex,STRINGDB
VWA5A
Tbio
Novelty: 0.08952043
p_int: 0.9962841
p_ni: 0.0037159
Data Source: BioPlex
FAM78A
Tdark
Novelty: 2.24659258
p_int: 0.978760116
p_ni: 0.021239883
p_wrong: 1e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
GPSM3
Tbio
Novelty: 0.0098187
p_int: 0.963296547
p_ni: 0.036698502
p_wrong: 0.000004951
Data Source: BioPlex
GIP
Tchem
Novelty: 0.00089192
p_int: 0.959684979
p_ni: 0.040260449
p_wrong: 0.000054571
Data Source: BioPlex
HDAC11
Tclin
Family: Epigenetic
Novelty: 0.00486766
p_int: 0.946203191
p_ni: 0.053697585
p_wrong: 0.000099224
Score: 0.184
Data Source: BioPlex,STRINGDB
CYP1A1
Tchem
Novelty: 0.00028982
p_int: 0.926668094
p_ni: 0.073331898
p_wrong: 8e-9
Data Source: BioPlex
BTN3A1
Tbio
Novelty: 0.03350752
p_int: 0.914210092
p_ni: 0.085784542
p_wrong: 0.000005366
Data Source: BioPlex
Publication Statistics
PubMed Score  57.19

PubMed score by year
PubTator Score  25.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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