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Tbio
STK39
STE20/SPS1-related proline-alanine-rich protein kinase

Protein Summary
Description
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT. This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355999
  • ENSP00000348278
  • ENSG00000198648

Symbol
  • SPAK
  • DCHT
  • PASK
  • SPAK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.96
PubMedID
0.84
transcription factor perturbation
0.8
transcription factor binding site profile
0.77


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.74   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 703   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.74   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 703   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
1
1.2
96.1
1
1
0
2
48.3
body mass index
1
1
2
34.9
red blood cell distribution width
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
96.1
0
2
48.3
body mass index
2
34.9
red blood cell distribution width
1
0.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 39
VGNC:2875
459711
Macaque
serine/threonine kinase 39
704855
Mouse
MGI:1858416
53416
Rat
RGD:621643
54348
Dog
serine/threonine kinase 39
VGNC:46921
478779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 39
Macaque
serine/threonine kinase 39
Mouse
Rat
Dog
serine/threonine kinase 39
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UEW8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (37)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (83)
1 – 10 of 83
RELL1
Tbio
Novelty: 0.28949625
p_int: 0.999999794
p_ni: 2.06e-7
Score: 0.53
Data Source: BioPlex,STRINGDB
RELT
Tbio
Novelty: 0.07977949
p_int: 0.999999737
p_ni: 2.63e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
RELL2
Tbio
Novelty: 0.59290726
p_int: 0.99999624
p_ni: 0.00000376
Score: 0.753
Data Source: BioPlex,STRINGDB
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.999603528
p_ni: 0.000396465
p_wrong: 7e-9
Data Source: BioPlex
LAMP2
Tbio
Novelty: 0.00168009
p_int: 0.998383272
p_ni: 0.001616728
Data Source: BioPlex
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.997215323
p_ni: 0.0024925
p_wrong: 0.000292177
Data Source: BioPlex
CST8
Tbio
Novelty: 0.02316886
p_int: 0.997205486
p_ni: 0.002786645
p_wrong: 0.000007869
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.990916463
p_ni: 0.009083508
p_wrong: 2.8e-8
Data Source: BioPlex
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.989517778
p_ni: 0.010482204
p_wrong: 1.8e-8
Data Source: BioPlex
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.988472886
p_ni: 0.00806482
p_wrong: 0.003462294
Data Source: BioPlex
Publication Statistics
PubMed Score  204.74

PubMed score by year
PubTator Score  102.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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