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Tbio
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

Protein Summary
Description
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554659
  • ENSP00000450731
  • ENSG00000100568

Symbol
  • VTI1
  • VTI1L
  • VTI1L1
  • VTI2
  • VTI1
  • VTI2
  • VTI1L
  • v-SNARE
  • vti1-rp1
  • VTI1-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.99
disease perturbation
0.98
cellular component
0.89
transcription factor perturbation
0.74


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.75   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.75   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle transport through interaction with t-SNAREs 1B
VGNC:6767
100615085
Macaque
vesicle transport through interaction with t-SNAREs 1B
711113
Mouse
MGI:1855688
53612
Rat
RGD:2323682
100359512
Dog
vesicle transport through interaction with t-SNAREs 1B
VGNC:48317
480365
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle transport through interaction with t-SNAREs 1B
Macaque
vesicle transport through interaction with t-SNAREs 1B
Mouse
Rat
Dog
vesicle transport through interaction with t-SNAREs 1B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UEU0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (33)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (292)
1 – 10 of 292
NAPG
Tbio
Novelty: 0.02295985
p_int: 0.999999837
p_ni: 1.63e-7
Score: 0.863
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999999479
p_ni: 5.21e-7
Score: 0.939
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.03109969
p_int: 0.999999148
p_ni: 8.52e-7
Score: 0.988
Data Source: BioPlex,STRINGDB
CWC22
Tbio
Novelty: 0.027689
p_int: 0.999966022
p_ni: 0.000033978
Data Source: BioPlex
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999898387
p_ni: 0.000101613
Score: 0.991
Data Source: BioPlex,STRINGDB
SESTD1
Tbio
Novelty: 0.2052002
p_int: 0.999891595
p_ni: 0.000108349
p_wrong: 5.6e-8
Data Source: BioPlex
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 0.999881108
p_ni: 0.000118878
p_wrong: 1.4e-8
Data Source: BioPlex
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999859344
p_ni: 0.000140656
Data Source: BioPlex
STX18
Tbio
Novelty: 0.0259034
p_int: 0.999824229
p_ni: 0.000175771
Score: 0.937
Data Source: BioPlex,STRINGDB
VAMP5
Tbio
Novelty: 0.09958312
p_int: 0.99917647
p_ni: 0.000823481
p_wrong: 5e-8
Score: 0.86
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  79.75

PubMed score by year
PubTator Score  104.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer