Tbio VTI1B Vesicle transport through interaction with t-SNAREs homolog 1B

Protein Summary

Description

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Uniprot Accession IDs

• Q9UEU0
• O43547
• Q96J28

Gene Name

• VTI1B

Ensembl ID

• ENST00000554659
• ENSP00000450731
• ENSG00000100568

Symbol

• VTI1
• VTI1L
• VTI1L1
• VTI2
• VTI1
• VTI2
• VTI1L
• v-SNARE
• vti1-rp1
• VTI1-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
kinase perturbation	0.99
disease perturbation	0.98
cellular component	0.89
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Vesicle Transport Through Interaction With T-snares Homolog 1b

DTO Classes

Protein / Transporter / Snare Protein / Vesicle Transport Through Interaction With T-snares Homolog 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0