You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DAXX
Death domain-associated protein 6

Protein Summary
Description
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266000
  • ENSP00000266000
  • ENSG00000204209
  • ENST00000374542
  • ENSP00000363668
  • ENST00000383062
  • ENSP00000372539
  • ENSG00000206206
  • ENST00000383194
  • ENSP00000372681
  • ENSG00000206279
  • ENST00000399060
  • ENSP00000382014
  • ENST00000399344
  • ENSP00000382281
  • ENST00000414083
  • ENSP00000396876
  • ENST00000433482
  • ENSP00000404623
  • ENSG00000231617
  • ENST00000436311
  • ENSP00000404376
  • ENSG00000227046
  • ENST00000445009
  • ENSP00000394108
  • ENST00000455860
  • ENSP00000410772
  • ENST00000612868
  • ENSP00000479172
  • ENST00000612888
  • ENSP00000483394
  • ENST00000613912
  • ENSP00000477633
  • ENST00000616312
  • ENSP00000483517
  • ENST00000617660
  • ENSP00000480448
  • ENST00000619421
  • ENSP00000478810
  • ENST00000620164
  • ENSP00000482399
  • ENST00000622655
  • ENSP00000484830

Symbol
  • BING2
  • DAP6
  • DAP6
  • EAP1
  • BING2
  • SMIM40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
biological process
0.96
molecular function
0.94
virus perturbation
0.94
virus
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.37   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 924   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 368.37   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 924   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0