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Tbio
DAXX
Death domain-associated protein 6

Protein Summary
Description
Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266000
  • ENSP00000266000
  • ENSG00000204209
  • ENST00000374542
  • ENSP00000363668
  • ENST00000383062
  • ENSP00000372539
  • ENSG00000206206
  • ENST00000383194
  • ENSP00000372681
  • ENSG00000206279
  • ENST00000399060
  • ENSP00000382014
  • ENST00000399344
  • ENSP00000382281
  • ENST00000414083
  • ENSP00000396876
  • ENST00000433482
  • ENSP00000404623
  • ENSG00000231617
  • ENST00000436311
  • ENSP00000404376
  • ENSG00000227046
  • ENST00000445009
  • ENSP00000394108
  • ENST00000455860
  • ENSP00000410772
  • ENST00000612868
  • ENSP00000479172
  • ENST00000612888
  • ENSP00000483394
  • ENST00000613912
  • ENSP00000477633
  • ENST00000616312
  • ENSP00000483517
  • ENST00000617660
  • ENSP00000480448
  • ENST00000619421
  • ENSP00000478810
  • ENST00000620164
  • ENSP00000482399
  • ENST00000622655
  • ENSP00000484830

Symbol
  • BING2
  • DAP6
  • DAP6
  • EAP1
  • BING2
  • SMIM40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
biological process
0.96
molecular function
0.94
virus perturbation
0.94
virus
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.39   (req: < 5)
Gene RIFs: 148   (req: <= 3)
Antibodies: 924   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.39   (req: >= 5)
Gene RIFs: 148   (req: > 3)
Antibodies: 924   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (256)
SENP7
Tchem
Family:  Enzyme
Novelty:  0.00955615
p_int:  0.99999998
p_ni:  1.9e-8
p_wrong:  1e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
ATRX
Tbio
Novelty:  0.00114798
p_int:  0.999999937
p_ni:  6.2e-8
Score:  0.96
Data Source:  BioPlex,STRINGDB
SETDB2
Tbio
Family:  TF; Epigenetic
Novelty:  0.05560622
p_int:  0.999999913
p_ni:  8.6e-8
p_wrong:  1e-9
Data Source:  BioPlex
MLLT10
Tbio
Family:  Epigenetic
Novelty:  0.00590548
p_int:  0.999999892
p_ni:  1.01e-7
p_wrong:  7e-9
Data Source:  BioPlex
TNRC18
Tdark
Novelty:  0.32654022
p_int:  0.999999028
p_ni:  9.72e-7
Data Source:  BioPlex
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.99999581
p_ni:  0.000004191
Score:  0.901
Data Source:  BioPlex,STRINGDB
ADNP
Tbio
Family:  TF
Novelty:  0.00785336
p_int:  0.999993895
p_ni:  0.000006105
Data Source:  BioPlex
MPHOSPH8
Tbio
Family:  Epigenetic
Novelty:  0.0534439
p_int:  0.999993709
p_ni:  0.00000629
p_wrong:  1e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
DOT1L
Tchem
Family:  Epigenetic
Novelty:  0.00361358
p_int:  0.999964797
p_ni:  0.000035203
Data Source:  BioPlex
BAZ1B
Tbio
Family:  Epigenetic
Novelty:  0.02374034
p_int:  0.999956701
p_ni:  0.000043299
p_wrong:  1e-9
Score:  0.225
Data Source:  BioPlex,STRINGDB
Pathways (31)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (50)
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
body mass index
1
1
1
63.4
Items per page:
1 – 5 of 50
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
body mass index
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
death domain associated protein
717590
Mouse
MGI:1197015
13163
Rat
RGD:621227
140926
Dog
death domain associated protein
VGNC:39777
474873
Cow
death domain associated protein
VGNC:27884
504336
Species
Name
OMA
EggNOG
Inparanoid
Macaque
death domain associated protein
Mouse
Rat
Dog
death domain associated protein
Cow
death domain associated protein
Publication Statistics
PubMed Score 338.39
PubMed score by year
PubTator Score 257.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title