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Tbio
KL
Klotho

Protein Summary
Description
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380099
  • ENSP00000369442
  • ENSG00000133116

Symbol
  • HFTC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
molecular function
0.84
protein domain
0.73
disease
0.72
histone modification site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1285.28   (req: < 5)
Gene RIFs: 288   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1285.28   (req: >= 5)
Gene RIFs: 288   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
FGF23
Tclin
Novelty:  0.00047318
Score:  0.999
Data Source:  Reactome,STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.968
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.94
Data Source:  STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.935
Data Source:  STRINGDB
IRS2
Tbio
Novelty:  0.00164304
Score:  0.92
Data Source:  STRINGDB
AKR1A1
Tchem
Family:  Enzyme
Novelty:  0.0054436
Score:  0.904
Data Source:  STRINGDB
TRPV5
Tchem
Family:  IC
Novelty:  0.0055156
Score:  0.879
Data Source:  STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.859
Data Source:  STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.854
Data Source:  Reactome,STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.848
Data Source:  STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 8
ATP1B1
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
FXYD2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
ATP1A1
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1A2
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1A3
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
Pathways (49)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

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Find Similar Targets
Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signaling of activated FGFR1
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signaling of activated FGFR1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
5
4
1.1
93.4
3
2
2
1.2
75
glucose measurement
2
2
2
70
hemoglobin measurement
2
1
2
59
hematocrit
2
1
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
93.4
2
1.2
75
glucose measurement
2
70
hemoglobin measurement
2
59
hematocrit
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
klotho
VGNC:5073
467257
Macaque
klotho
714042
Mouse
MGI:1101771
16591
Rat
RGD:620396
83504
Dog
klotho
VGNC:42425
100685604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
klotho
Macaque
klotho
Mouse
Rat
Dog
klotho
Publication Statistics
PubMed Score 1285.28
PubMed score by year
PubTator Score 520.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title