Tchem STK17A Serine/threonine-protein kinase 17A

Protein Summary

Description

Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UEE5
• A4D1V6
• Q8IVC8

Gene Name

• STK17A

Ensembl ID

• ENST00000319357
• ENSP00000319192
• ENSG00000164543
• ENST00000648544
• ENSP00000497301

Symbol

• DRAK1
• DRAK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule	0.92
molecular function	0.9
co-expressed gene	0.89
PubMedID	0.87
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase 17a

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Dapk Family / Serine/threonine-protein Kinase 17a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2