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Tchem
STK17A
Serine/threonine-protein kinase 17A

Protein Summary
Description
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319357
  • ENSP00000319192
  • ENSG00000164543
  • ENST00000648544
  • ENSP00000497301

Symbol
  • DRAK1
  • DRAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.92
molecular function
0.9
co-expressed gene
0.89
PubMedID
0.87
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.37   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.37   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
52.4
mean reticulocyte volume
1
1
1
40
mean corpuscular volume
1
1
1
32.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
52.4
mean reticulocyte volume
1
40
mean corpuscular volume
1
32.8
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (19)
1 – 10 of 19
MCHR2
Tchem
Family: GPCR
Novelty: 0.01191922
Score: 0.65
Data Source: STRINGDB
COL21A1
Tbio
Novelty: 0.1583142
Score: 0.649
Data Source: STRINGDB
DAP
Tbio
Novelty: 0.06401402
Score: 0.601
Data Source: STRINGDB
MFSD6
Tbio
Novelty: 0.0161011
Score: 0.525
Data Source: STRINGDB
TMTC2
Tbio
Novelty: 0.17232458
Score: 0.477
Data Source: STRINGDB
ARHGEF19
Tbio
Novelty: 0.21876325
Score: 0.477
Data Source: STRINGDB
CPVL
Tbio
Family: Enzyme
Novelty: 0.0616903
Score: 0.474
Data Source: STRINGDB
SPSB4
Tdark
Novelty: 0.07251424
Score: 0.474
Data Source: STRINGDB
PPP1R1A
Tbio
Family: Enzyme
Novelty: 0.01565981
Score: 0.467
Data Source: STRINGDB
NOSIP
Tbio
Family: Enzyme
Novelty: 0.05605921
Score: 0.456
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.37

PubMed score by year
PubTator Score  11.41

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer