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Tchem
STK17A
Serine/threonine-protein kinase 17A

Protein Summary
Description
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319357
  • ENSP00000319192
  • ENSG00000164543
  • ENST00000648544
  • ENSP00000497301

Symbol
  • DRAK1
  • DRAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
0.92
molecular function
0.9
co-expressed gene
0.89
PubMedID
0.87
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.75   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.75   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (19)
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.65
Data Source:  STRINGDB
COL21A1
Tbio
Novelty:  0.1583142
Score:  0.649
Data Source:  STRINGDB
DAP
Tbio
Novelty:  0.06401402
Score:  0.601
Data Source:  STRINGDB
MFSD6
Tbio
Novelty:  0.0161011
Score:  0.525
Data Source:  STRINGDB
TMTC2
Tbio
Novelty:  0.17232458
Score:  0.477
Data Source:  STRINGDB
ARHGEF19
Tbio
Novelty:  0.21876325
Score:  0.477
Data Source:  STRINGDB
CPVL
Tbio
Family:  Enzyme
Novelty:  0.0616903
Score:  0.474
Data Source:  STRINGDB
SPSB4
Tdark
Novelty:  0.07251424
Score:  0.474
Data Source:  STRINGDB
PPP1R1A
Tbio
Family:  Enzyme
Novelty:  0.01565981
Score:  0.467
Data Source:  STRINGDB
NOSIP
Tbio
Family:  Enzyme
Novelty:  0.05605921
Score:  0.456
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
70.2
mean corpuscular volume
1
1
1
62.5
mean corpuscular hemoglobin concentration
1
1
1
51.4
pulmonary non-tuberculous mycobacterial infection
1
1
0
1.3
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
70.2
mean corpuscular volume
1
62.5
mean corpuscular hemoglobin concentration
1
51.4
pulmonary non-tuberculous mycobacterial infection
0
1.3
0.2
Find similar targets by:
IDG Resources
Chemical Tool
N-(3-((5-cyclopropyl-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide
image for N-(3-((5-cyclopropyl-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)propyl)cyclobutanecarboxamide
Details:
  • ChEBI:  156468
  • Provider:  UNC-CH
  • Activity:  NA
  • Selectivity:  NA
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 17a
VGNC:4521
472352
Macaque
serine/threonine kinase 17a
701091
Dog
serine/threonine kinase 17a
VGNC:46907
483241
Horse
serine/threonine kinase 17a
VGNC:23683
100064585
Cow
serine/threonine kinase 17a
VGNC:53673
513665
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 17a
Macaque
serine/threonine kinase 17a
Dog
serine/threonine kinase 17a
Horse
serine/threonine kinase 17a
Cow
serine/threonine kinase 17a
Publication Statistics
PubMed Score 24.75
PubMed score by year
PubTator Score 11.41
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title