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Tchem
MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Protein Summary
Description
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345724
  • ENSP00000304161
  • ENSG00000172175
  • ENST00000348428
  • ENSP00000319279
  • ENST00000649217
  • ENSP00000497997

Symbol
  • MLT
  • MLT
  • MLT1
  • IMD12
  • PCASP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.97
kinase perturbation
0.81
histone modification site profile
0.8
transcription factor
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.63   (req: < 5)
Gene RIFs: 157   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.63   (req: >= 5)
Gene RIFs: 157   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 115
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1