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Tchem
MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Protein Summary
Description
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345724
  • ENSP00000304161
  • ENSG00000172175
  • ENST00000348428
  • ENSP00000319279
  • ENST00000649217
  • ENSP00000497997

Symbol
  • MLT
  • MLT
  • MLT1
  • IMD12
  • PCASP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
protein domain
0.97
kinase perturbation
0.81
histone modification site profile
0.8
transcription factor
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.69   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 670   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.69   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 670   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (100)
TRIB1
Tbio
Family:  Kinase
Novelty:  0.01587891
p_int:  0.999999898
p_ni:  1e-7
p_wrong:  2e-9
Score:  0.359
Data Source:  BioPlex,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.99919865
p_ni:  0.000044343
p_wrong:  0.000757007
Data Source:  BioPlex
BCL10
Tbio
Novelty:  0.00253704
Score:  0.999
Data Source:  Reactome,STRINGDB
CARD11
Tbio
Family:  Enzyme
Novelty:  0.00716457
Score:  0.995
Data Source:  Reactome,STRINGDB
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
Score:  0.994
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.987
Data Source:  Reactome,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.979
Data Source:  Reactome,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.975
Data Source:  Reactome,STRINGDB
CARD10
Tbio
Family:  Enzyme
Novelty:  0.01960502
Score:  0.974
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.968
Data Source:  Reactome,STRINGDB
Pathways (30)
Activation of NF-kappaB in B cells (R-HSA-1169091)

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Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
CLEC7A/inflammasome pathway
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
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Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
63.6
eosinophil percentage of leukocytes
1
1
1
51.4
eosinophil count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
63.6
eosinophil percentage of leukocytes
1
51.4
eosinophil count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MALT1 paracaspase
VGNC:7319
468549
Macaque
MALT1 paracaspase
696354
Mouse
MGI:2445027
240354
Rat
RGD:1309195
307366
Dog
MALT1 paracaspase
VGNC:42936
476188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MALT1 paracaspase
Macaque
MALT1 paracaspase
Mouse
Rat
Dog
MALT1 paracaspase
Publication Statistics
PubMed Score 328.69
PubMed score by year
PubTator Score 253.41
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title