Tbio TRIM10 Tripartite motif-containing protein 10

Protein Summary

Description

Seems to play an important role in erythropoiesis. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UDY6
• A6NF84
• Q5SRJ5
• Q5SRK8
• Q86Z08
• Q96QB6
• Q9C023
• Q9C024

Gene Name

• TRIM10

Ensembl ID

• ENST00000259941
• ENSP00000259941
• ENSG00000137394
• ENST00000354038
• ENSP00000343695
• ENST00000376704
• ENSP00000365894
• ENSG00000204613
• ENST00000413055
• ENSP00000393787
• ENSG00000227472
• ENST00000416714
• ENSP00000405578
• ENSG00000229381
• ENST00000417411
• ENSP00000393576
• ENSG00000237192
• ENST00000426996
• ENSP00000397440
• ENST00000428611
• ENSP00000412370
• ENSG00000229346
• ENST00000431258
• ENSP00000395598
• ENSG00000235025
• ENST00000446013
• ENSP00000398404
• ENSG00000237703
• ENST00000447465
• ENSP00000393976
• ENST00000448645
• ENSP00000399446
• ENST00000449208
• ENSP00000390497
• ENST00000449742
• ENSP00000397073
• ENST00000451727
• ENSP00000391445
• ENST00000456988
• ENSP00000410849

Symbol

• RFB30
• RNF9
• RNF9
• HERF1
• RFB30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
microRNA	0.61
cell type or tissue	0.57
phenotype	0.57
disease perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.9   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.9   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0