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Tbio
TJP2
Tight junction protein ZO-2

Protein Summary
Description
Plays a role in tight junctions and adherens junctions. This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348208
  • ENSP00000345893
  • ENSG00000119139
  • ENST00000377245
  • ENSP00000366453
  • ENST00000453658
  • ENSP00000392178
  • ENST00000535702
  • ENSP00000442090
  • ENST00000539225
  • ENSP00000438262
  • ENST00000648204
  • ENSP00000497941

Symbol
  • X104
  • ZO2
  • ZO2
  • X104
  • PFIC4
  • DFNA51
  • DUP9q21.11
  • C9DUPq21.11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
hub protein
0.94
transcription factor perturbation
0.88
drug perturbation
0.87
kinase
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.98   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.98   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0