Tbio MTFP1 Mitochondrial fission process protein 1

Protein Summary

Description

Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9UDX5
• A6NFQ5
• Q9H3K1
• Q9P0N6

Gene Name

• MTFP1

Ensembl ID

• ENST00000266263
• ENSP00000266263
• ENSG00000242114
• ENST00000355143
• ENSP00000347267

Symbol

• MTP18
• MTP18
• HSPC242

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
kinase perturbation	0.71
small molecule perturbation	0.63
tissue	0.6
cellular component	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.97   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 92   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.97   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0