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Tbio
SEC14L4
SEC14-like protein 4

Protein Summary
Description
Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids. The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255858
  • ENSP00000255858
  • ENSG00000133488
  • ENST00000381982
  • ENSP00000371412

Symbol
  • TAP3
  • TAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
protein domain
0.58
tissue
0.54
disease
0.46
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
93.1
mean corpuscular volume
1
2
2
61.8
reticulocyte measurement
2
2
3
61.8
high density lipoprotein cholesterol measurement
1
1
1
61.4
apolipoprotein A 1 measurement
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
93.1
mean corpuscular volume
2
61.8
reticulocyte measurement
3
61.8
high density lipoprotein cholesterol measurement
1
61.4
apolipoprotein A 1 measurement
1
61
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC14 like lipid binding 4
VGNC:6712
470176
Macaque
putative SEC14-like protein 6
100428362
Mouse
MGI:2144095
103655
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC14 like lipid binding 4
Macaque
putative SEC14-like protein 6
Mouse
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UDX3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (17)
1 – 10 of 17
SEC14L3
Tbio
Novelty:  0.15067161
p_int:  1
Score:  0.698
Data Source:  BioPlex,STRINGDB
PITPNB
Tbio
Novelty:  0.03432693
Score:  0.601
Data Source:  STRINGDB
PITPNA
Tbio
Novelty:  0.01901136
Score:  0.586
Data Source:  STRINGDB
PITPNM2
Tbio
Novelty:  0.0757684
Score:  0.53
Data Source:  STRINGDB
CPSF4L
Tdark
Novelty:  4.27116708
Score:  0.515
Data Source:  STRINGDB
C1orf162
Tdark
Novelty:  4.98517033
Score:  0.51
Data Source:  STRINGDB
PITPNM3
Tbio
Novelty:  0.02122312
Score:  0.502
Data Source:  STRINGDB
PITPNC1
Tbio
Novelty:  0.09338428
Score:  0.501
Data Source:  STRINGDB
PITPNM1
Tbio
Novelty:  0.0063062
Score:  0.501
Data Source:  STRINGDB
ZNF502
Tbio
Family:  TF
Novelty:  1.32301434
Score:  0.497
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.30

PubMed score by year
PubTator Score  9.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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