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Tbio
UQCR10
Cytochrome b-c1 complex subunit 9

Protein Summary
Description
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1 (By similarity). UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330029
  • ENSP00000332887
  • ENSG00000184076
  • ENST00000401406
  • ENSP00000384962

Symbol
  • UCRC
  • QCR9
  • UCRC
  • HSPC051
  • HSPC119
  • HSPC151
  • UCCR7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.95
histone modification site profile
0.94
ligand (protein) perturbation
0.83
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
p_int:  0.817757177
p_ni:  0.182242317
p_wrong:  5.06e-7
Data Source:  BioPlex
CYC1
Tchem
Novelty:  0.01369865
Score:  0.999
Data Source:  STRINGDB
UQCRC2
Tbio
Family:  Enzyme
Novelty:  0.01584406
Score:  0.999
Data Source:  STRINGDB
UQCRQ
Tbio
Novelty:  0.04392627
Score:  0.999
Data Source:  STRINGDB
UQCRB
Tbio
Novelty:  0.02933046
Score:  0.999
Data Source:  STRINGDB
UQCR11
Tbio
Novelty:  0.08583842
Score:  0.999
Data Source:  STRINGDB
UQCRFS1
Tbio
Novelty:  0.00341256
Score:  0.999
Data Source:  STRINGDB
UQCRH
Tbio
Novelty:  0.04494433
Score:  0.999
Data Source:  STRINGDB
UQCRC1
Tbio
Family:  Enzyme
Novelty:  0.01746759
Score:  0.999
Data Source:  STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
79.6
self reported educational attainment
2
2
2
78.2
serum non-albumin protein measurement
1
2
2
71.7
reticulocyte count
2
2
2
71.5
glomerular filtration rate
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
79.6
self reported educational attainment
2
78.2
serum non-albumin protein measurement
2
71.7
reticulocyte count
2
71.5
glomerular filtration rate
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913402
66152
Rat
RGD:1595126
685322
Dog
ubiquinol-cytochrome c reductase, complex III subunit X
VGNC:48162
486347
Cow
ubiquinol-cytochrome c reductase, complex III subunit X
VGNC:36693
616109
Pig
ubiquinol-cytochrome c reductase complex 7.2 kDa protein
100155687
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase, complex III subunit X
Cow
ubiquinol-cytochrome c reductase, complex III subunit X
Pig
ubiquinol-cytochrome c reductase complex 7.2 kDa protein
Publication Statistics
PubMed Score 23.04
PubMed score by year
PubTator Score 4.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title