Tdark ZNF212 Zinc finger protein 212

Protein Summary

Description

May be involved in transcriptional regulation. This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UDV6
• B2RCF4
• Q13396
• Q8N664

Gene Name

• ZNF212

Ensembl ID

• ENST00000335870
• ENSP00000338572
• ENSG00000170260

Symbol

• ZNFC150
• ZNF182
• ZNFC150
• C2H2-150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
kinase perturbation	0.81
histone modification site profile	0.77
protein domain	0.73
disease perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.15   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.15   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (26)

Explore Interacting Targets

1 – 10 of 26

• See Interactions on String-DB

ADO

Tbio

Family:  Enzyme

Novelty:  0.04529593

p_int:  0.999995381

p_ni:  0.000003124

p_wrong:  0.000001495

Score:  0.209

Data Source:  BioPlex,STRINGDB

ZNF398

Tbio

Family:  TF

Novelty:  0.01578856

p_int:  0.999993342

p_ni:  3e-9

p_wrong:  0.000006655

Score:  0.869

Data Source:  BioPlex,STRINGDB

ZNF282

Tdark

Family:  TF

Novelty:  0.32333465

p_int:  0.999983304

p_ni:  0.000016148

p_wrong:  5.48e-7

Score:  0.884

Data Source:  BioPlex,STRINGDB

ZNF746

Tbio

Family:  TF

Novelty:  0.10426864

p_int:  0.999948879

p_ni:  0.000051115

p_wrong:  6e-9

Score:  0.847

Data Source:  BioPlex,STRINGDB

ERP44

Tbio

Novelty:  0.02352693

p_int:  0.999780298

p_ni:  0.000219702

Score:  0.337

Data Source:  BioPlex,STRINGDB

EPDR1

Tbio

Novelty:  0.03597825

p_int:  0.992368083

p_ni:  0.007630617

p_wrong:  0.0000013

Score:  0.188

Data Source:  BioPlex,STRINGDB

ZNF777

Tdark

Family:  TF

Novelty:  1.20195224

p_int:  0.979403961

p_ni:  0.020596038

p_wrong:  1e-9

Score:  0.825

Data Source:  BioPlex,STRINGDB

DIS3

Tbio

Family:  Enzyme

Novelty:  0.00961238

p_int:  0.787833835

p_ni:  0.212166165

Score:  0.177

Data Source:  BioPlex,STRINGDB

TRIM28

Tbio

Family:  Epigenetic

Novelty:  0.00778381

Score:  0.927

Data Source:  STRINGDB

OR10H2

Tdark

Family:  oGPCR

Novelty:  0.97435897

Score:  0.67

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Gene expression (Transcription) (R-HSA-74160)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
RNA Polymerase II Transcription	1314 targets	R-HSA-73857

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (4)

Components (1)

Processes (1)

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Items per page:

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1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
zinc ion binding	Non-traceable Author Statement (NAS)	UniProtKB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3	2	3		89.4
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		89
eosinophil percentage of granulocytes	EFO_0007996	1	1	1		82.6
neutrophil percentage of granulocytes	EFO_0007994	1	1	1		82.1
sum of eosinophil and basophil counts	EFO_0009389	1	1	1		78.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		89.4
eosinophil percentage of leukocytes	EFO_0007991	2		89
eosinophil percentage of granulocytes	EFO_0007996	1		82.6
neutrophil percentage of granulocytes	EFO_0007994	1		82.1
sum of eosinophil and basophil counts	EFO_0009389	1		78.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Metal-binding
Nucleus
Polymorphism
Reference proteome
Repeat
Transcription
Transcription regulation
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
heel bone mineral density
leukocyte count
myeloid white cell count
neutrophil count
neutrophil percentage of granulocytes
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 212	VGNC:8794	745702
Macaque	zinc finger protein 212		711572
Mouse	Zinc finger protein 212	MGI:2682609	232784
Rat	Zinc finger protein 212	RGD:1307836	297066
Horse	zinc finger protein 212	VGNC:25278	100060969

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 212
Macaque	zinc finger protein 212
Mouse	Zinc finger protein 212
Rat	Zinc finger protein 212
Horse	zinc finger protein 212

Publication Statistics

PubMed Score 1.15

PubMed score by year

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PubTator Score 0.13

PubTator score by year

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Related Publications

Text Mined References (11)

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10

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PMID	Year	Title