Tbio CLIP2 CAP-Gly domain-containing linker protein 2

Protein Summary

Description

Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity). The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UDT6
• O14527
• O43611

Gene Name

• CLIP2

Ensembl ID

• ENST00000223398
• ENSP00000223398
• ENSG00000106665
• ENST00000361545
• ENSP00000355151
• ENST00000395060
• ENSP00000378500

Symbol

• CYLN2
• KIAA0291
• WBSCR3
• WBSCR4
• WSCR4
• CLIP
• CYLN2
• WSCR3
• WSCR4
• WBSCR3
• WBSCR4
• CLIP-115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
transcription factor binding site profile	0.65
tissue sample	0.64
ligand (protein) perturbation	0.59
cell type or tissue	0.55

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Cap-gly Domain-containing Linker Protein 2

Protein / Chaperone / Cap-gly Domain-containing Linker Protein 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Cap-gly Domain-containing Linker Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.49   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.49   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0