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Tbio
PPP1R1B
Protein phosphatase 1 regulatory subunit 1B

Protein Summary
Description
Inhibitor of protein-phosphatase 1. This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254079
  • ENSP00000254079
  • ENSG00000131771
  • ENST00000394265
  • ENSP00000377808
  • ENST00000394267
  • ENSP00000377810
  • ENST00000580825
  • ENSP00000462137

Symbol
  • DARPP32
  • DARPP32
  • DARPP-32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
chemical
0.81
molecular function
0.81
phosphatase
0.81
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.49   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 556.49   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (17)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
GPCR downstream signalling
Opioid Signalling
Signal Transduction
Gene Ontology Terms (28)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (136)
1 – 10 of 136
ACTBL2
Tbio
Novelty: 0.35273907
p_int: 0.891143908
p_ni: 0.108856092
Score: 0.161
Data Source: BioPlex,STRINGDB
CDK5
Tchem
Family: Kinase
Novelty: 0.00081843
Score: 0.995
Data Source: STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00685545
Score: 0.956
Data Source: STRINGDB
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.07465785
Score: 0.936
Data Source: STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.05996003
Score: 0.935
Data Source: STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00538884
Score: 0.93
Data Source: STRINGDB
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01848436
Score: 0.928
Data Source: STRINGDB
CDK5R1
Tchem
Family: Enzyme
Novelty: 0.01582689
Score: 0.926
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00238194
Score: 0.923
Data Source: STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00655436
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  556.49

PubMed score by year
PubTator Score  218.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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