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Tbio
PPP1R1B
Protein phosphatase 1 regulatory subunit 1B

Protein Summary
Description
Inhibitor of protein-phosphatase 1. This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254079
  • ENSP00000254079
  • ENSG00000131771
  • ENST00000394265
  • ENSP00000377808
  • ENST00000394267
  • ENSP00000377810
  • ENST00000580825
  • ENSP00000462137

Symbol
  • DARPP32
  • DARPP32
  • DARPP-32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.83
chemical
0.81
molecular function
0.81
phosphatase
0.81
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.81   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 683   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 718.81   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 683   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.891143908
p_ni:  0.108856092
Score:  0.161
Data Source:  BioPlex,STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.995
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.956
Data Source:  STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
Score:  0.936
Data Source:  STRINGDB
PRKACA
Tchem
Family:  Kinase
Novelty:  0.03869658
Score:  0.935
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.93
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.928
Data Source:  STRINGDB
CDK5R1
Tchem
Family:  Enzyme
Novelty:  0.01065962
Score:  0.926
Data Source:  STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
Score:  0.923
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
Pathways (17)
DARPP-32 events (R-HSA-180024)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DARPP-32 events
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Opioid Signalling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
DARPP-32 events
G alpha (i) signalling events
GPCR downstream signalling
Opioid Signalling
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
9
18
98.1
glomerular filtration rate
3
3
3
94.5
alkaline phosphatase measurement
2
2
1
11.6
93.4
3
3
0
1.1
92.7
hemoglobin measurement
2
2
2
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
98.1
glomerular filtration rate
3
94.5
alkaline phosphatase measurement
1
11.6
93.4
0
1.1
92.7
hemoglobin measurement
2
84.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 1B
VGNC:9534
744755
Macaque
protein phosphatase 1 regulatory inhibitor subunit 1B
574203
Mouse
MGI:94860
19049
Rat
RGD:621859
360616
Dog
protein phosphatase 1 regulatory inhibitor subunit 1B
VGNC:44887
608394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 1B
Macaque
protein phosphatase 1 regulatory inhibitor subunit 1B
Mouse
Rat
Dog
protein phosphatase 1 regulatory inhibitor subunit 1B
Publication Statistics
PubMed Score 718.81
PubMed score by year
PubTator Score 218.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title