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Tbio
REV1
DNA repair protein REV1

Protein Summary
Description
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258428
  • ENSP00000258428
  • ENSG00000135945
  • ENST00000393445
  • ENSP00000377091

Symbol
  • REV1L
  • REV1L
  • AIBP80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.73
protein domain
0.73
cell type or tissue
0.71
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.22   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.22   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
96
cognitive function measurement
1
1
1
54.7
self reported educational attainment
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
96
cognitive function measurement
1
54.7
self reported educational attainment
1
39.5
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
REV1, DNA directed polymerase
VGNC:8257
742931
Mouse
MGI:1929074
56210
Rat
RGD:1306715
316344
Dog
REV1, DNA directed polymerase
VGNC:45487
481337
Horse
REV1, DNA directed polymerase
VGNC:22313
100050347
Species
Name
OMA
EggNOG
Inparanoid
Chimp
REV1, DNA directed polymerase
Mouse
Rat
Dog
REV1, DNA directed polymerase
Horse
REV1, DNA directed polymerase
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBZ9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Termination of translesion DNA synthesis
Reactome
Translesion synthesis by POLI
Reactome
Translesion synthesis by POLK
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Termination of translesion DNA synthesis
Translesion synthesis by POLI
Translesion synthesis by POLK
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (166)
1 – 10 of 166
MAD2L2
Tbio
Novelty: 0.01091072
Score: 0.999
Data Source: Reactome,STRINGDB
REV3L
Tbio
Family: Enzyme
Novelty: 0.00411916
Score: 0.999
Data Source: Reactome,STRINGDB
POLK
Tbio
Family: Enzyme
Novelty: 0.01378154
Score: 0.998
Data Source: Reactome,STRINGDB
POLD3
Tbio
Family: Enzyme
Novelty: 0.02646621
Score: 0.992
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.991
Data Source: Reactome,STRINGDB
POLH
Tchem
Family: Enzyme
Novelty: 0.00458533
Score: 0.99
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.99
Data Source: STRINGDB
POLI
Tchem
Family: Enzyme
Novelty: 0.00042246
Score: 0.988
Data Source: Reactome,STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.984
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  344.22

PubMed score by year
PubTator Score  148.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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