Tbio HSPB7 Heat shock protein beta-7

Protein Summary

Description

This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9UBY9
• B3KQ37
• C9K0Y0
• Q9NU17
• HspB7

Gene Name

• HSPB7

Ensembl ID

• ENST00000311890
• ENSP00000310111
• ENSG00000173641
• ENST00000487046
• ENSP00000419477

Symbol

• CVHSP
• cvHSP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.61
tissue sample	0.6
gene perturbation	0.51
cell line	0.5
disease	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.51   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 234   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.51   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 234   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0