LPAR3
Lysophosphatidic acid receptor 3
Protein Summary
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
- ENST00000370611
- ENSP00000359643
- ENSG00000171517
- ENST00000440886
- ENSP00000395389
- EDG7
- LPA3
- EDG7
- GPCR
- LPA3
- Edg-7
- LP-A3
- HOFNH30
- RP4-678I3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
virus perturbation | 0.97 | ||
biological process | 0.87 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.92 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 305 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 185.92 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 305 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 49
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0