Protein Summary
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
- ENST00000319720
- ENSP00000324269
- ENSG00000167757
- ENST00000391804
- ENSP00000375680
- ENST00000453757
- ENSP00000413958
- ENST00000594768
- ENSP00000473047
- PRSS20
- TLSP
- TLSP
- PRSS20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.86 | ||
PubMedID | 0.65 | ||
protein domain | 0.58 | ||
tissue | 0.53 | ||
cellular component | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.12 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 317 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 346.12 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 317 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (36)
SPSB3
Novelty: 0.07215887
p_int: 0.999001572
p_ni: 0.000263259
p_wrong: 0.000735169
Score: 0.224
Data Source: BioPlex,STRINGDB
TGFBR3
Novelty: 0.0077307
p_int: 0.998425026
p_ni: 0.001574241
p_wrong: 7.32e-7
Data Source: BioPlex
LOXL2
Family: Enzyme
Novelty: 0.00599536
p_int: 0.995782846
p_ni: 0.004217154
Data Source: BioPlex
FTH1
Novelty: 0.000863
p_int: 0.988211163
p_ni: 0.00002919
p_wrong: 0.011759647
Score: 0.155
Data Source: BioPlex,STRINGDB
LCHN
Novelty: 0.08678963
p_int: 0.981516893
p_ni: 0.018483107
Score: 0.188
Data Source: BioPlex,STRINGDB
POLE2
Family: Enzyme
Novelty: 0.03129531
p_int: 0.951867615
p_ni: 0.04808588
p_wrong: 0.000046505
Data Source: BioPlex
MOCOS
Family: Enzyme
Novelty: 0.05022905
p_int: 0.945716094
p_ni: 0.04873292
p_wrong: 0.005550985
Data Source: BioPlex
GALNT11
Family: Enzyme
Novelty: 0.09714947
p_int: 0.917840516
p_ni: 0.082159481
p_wrong: 3e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 3 | 5 | 91.6 | |||||
blood protein measurement | 1 | 2 | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 1 | 1 | 87.2 | |||||
kallikrein-11 measurement | 1 | 1 | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 1 | 1 | 38.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vitamin D measurement | 5 | 91.6 | |||||
blood protein measurement | 2 | 89.8 | |||||
kallikreinâ6 measurement | 1 | 87.2 | |||||
kallikrein-11 measurement | 0 | 1.5 | 69.5 | ||||
C-reactive protein measurement | 1 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 11 | VGNC:2331 | 468974 | |||||
Mouse | MGI:1929977 | 56538 | ||||||
Rat | RGD:1308690 | 292849 | ||||||
Dog | kallikrein related peptidase 11 | VGNC:42479 | 476401 | |||||
Horse | kallikrein related peptidase 11 | VGNC:19483 | 100067130 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | kallikrein related peptidase 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | kallikrein related peptidase 11 | |||||
Horse | kallikrein related peptidase 11 | |||||
Publication Statistics
PubMed Score 346.12
PubMed score by year
PubTator Score 101.81
PubTator score by year
Related Publications
Text Mined References (43)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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