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Tbio
KLK11
Kallikrein-11

Protein Summary
Description
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319720
  • ENSP00000324269
  • ENSG00000167757
  • ENST00000391804
  • ENSP00000375680
  • ENST00000453757
  • ENSP00000413958
  • ENST00000594768
  • ENSP00000473047

Symbol
  • PRSS20
  • TLSP
  • TLSP
  • PRSS20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
PubMedID
0.65
protein domain
0.58
tissue
0.53
cellular component
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.12   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.12   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.999001572
p_ni:  0.000263259
p_wrong:  0.000735169
Score:  0.224
Data Source:  BioPlex,STRINGDB
TGFBR3
Tbio
Novelty:  0.0077307
p_int:  0.998425026
p_ni:  0.001574241
p_wrong:  7.32e-7
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.995782846
p_ni:  0.004217154
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.988211163
p_ni:  0.00002919
p_wrong:  0.011759647
Score:  0.155
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.986355692
p_ni:  0.013644308
Data Source:  BioPlex
LCHN
Tdark
Novelty:  0.08678963
p_int:  0.981516893
p_ni:  0.018483107
Score:  0.188
Data Source:  BioPlex,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
p_int:  0.951867615
p_ni:  0.04808588
p_wrong:  0.000046505
Data Source:  BioPlex
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.949947203
p_ni:  0.050052796
Data Source:  BioPlex
MOCOS
Tbio
Family:  Enzyme
Novelty:  0.05022905
p_int:  0.945716094
p_ni:  0.04873292
p_wrong:  0.005550985
Data Source:  BioPlex
GALNT11
Tbio
Family:  Enzyme
Novelty:  0.09714947
p_int:  0.917840516
p_ni:  0.082159481
p_wrong:  3e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
kallikrein-11 measurement
1
1
0
1.5
69.5
C-reactive protein measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
kallikrein-11 measurement
0
1.5
69.5
C-reactive protein measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 11
VGNC:2331
468974
Mouse
MGI:1929977
56538
Rat
RGD:1308690
292849
Dog
kallikrein related peptidase 11
VGNC:42479
476401
Horse
kallikrein related peptidase 11
VGNC:19483
100067130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kallikrein related peptidase 11
Mouse
Rat
Dog
kallikrein related peptidase 11
Horse
kallikrein related peptidase 11
Publication Statistics
PubMed Score 346.12
PubMed score by year
PubTator Score 101.81
PubTator score by year
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Related Publications
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PMID
Year
Title