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Tbio
FBLN5
Fibulin-5

Protein Classes
Protein Summary
Description
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342058
  • ENSP00000345008
  • ENSG00000140092

Symbol
  • DANCE
  • EVEC
  • UP50
  • ADCL2
  • ARMD3
  • DANCE
  • ARCL1A
  • FIBL-5
  • HNARMD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
protein domain
0.92
virus perturbation
0.9
virus
0.89
disease
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.34   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.34   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
2
2
5.7
79.8
optic disc size measurement
1
1
1
16.6
BMI-adjusted waist circumference
2
1
3
1.8
heel bone mineral density
1
1
1
1.3
smoking behavior
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
5.7
79.8
optic disc size measurement
1
16.6
BMI-adjusted waist circumference
3
1.8
heel bone mineral density
1
1.3
smoking behavior
1
0.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fibulin 5
697372
Mouse
MGI:1346091
23876
Rat
RGD:2594
29158
Dog
fibulin 5
VGNC:40752
480227
Horse
fibulin 5
VGNC:17932
100063331
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fibulin 5
Mouse
Rat
Dog
fibulin 5
Horse
fibulin 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (73)
1 – 10 of 73
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.999919563
p_ni: 0.000080436
p_wrong: 1e-9
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.999877606
p_ni: 0.00012232
p_wrong: 7.4e-8
Data Source: BioPlex
TKTL2
Tbio
Family: Enzyme
Novelty: 0.0915871
p_int: 0.999780839
p_ni: 0.000219151
p_wrong: 1e-8
Score: 0.314
Data Source: BioPlex,STRINGDB
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.999648909
p_ni: 0.000197381
p_wrong: 0.00015371
Data Source: BioPlex
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.999064834
p_ni: 0.000935078
p_wrong: 8.8e-8
Data Source: BioPlex
HRG
Tbio
Novelty: 0.0027048
p_int: 0.998747991
p_ni: 0.001250379
p_wrong: 0.00000163
Data Source: BioPlex
ZNF550
Tdark
Family: TF
Novelty: 18
p_int: 0.994504495
p_ni: 0.004422383
p_wrong: 0.001073123
Score: 0.191
Data Source: BioPlex,STRINGDB
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.982157509
p_ni: 0.016036272
p_wrong: 0.00180622
Data Source: BioPlex
ELN
Tbio
Novelty: 0.00026801
Score: 0.993
Data Source: Reactome,STRINGDB
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
Score: 0.989
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  182.34

PubMed score by year
PubTator Score  118.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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