DUX4
Double homeobox protein 4
Protein Summary
Involved in transcriptional regulation. May regulate microRNA (miRNA) expression. This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000565211
- ENSP00000458065
- ENSG00000260596
- ENST00000569241
- ENSP00000456539
- ENST00000616166
- ENSP00000483555
- DUX10
- DUX4L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.77 | ||
protein domain | 0.41 | ||
protein complex | 0.4 | ||
phenotype | 0.36 | ||
biological term | 0.35 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.37 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 256 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 129.37 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 256 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0