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Tbio
DUX4
Double homeobox protein 4

Protein Summary
Description
Involved in transcriptional regulation. May regulate microRNA (miRNA) expression. This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000565211
  • ENSP00000458065
  • ENSG00000260596
  • ENST00000569241
  • ENSP00000456539
  • ENST00000616166
  • ENSP00000483555

Symbol
  • DUX10
  • DUX4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.77
protein domain
0.41
protein complex
0.4
phenotype
0.36
biological term
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.62   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.62   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
FRG2
Tbio
Novelty:  0.0630713
Score:  0.876
Data Source:  STRINGDB
SMCHD1
Tbio
Novelty:  0.01383021
Score:  0.86
Data Source:  STRINGDB
ETV5
Tbio
Family:  TF
Novelty:  0.00052506
Score:  0.806
Data Source:  STRINGDB
DUX4L7
Tdark
Novelty:  0.00860736
Score:  0.801
Data Source:  STRINGDB
DUX4L4
Tdark
Novelty:  6.72426785
Score:  0.8
Data Source:  STRINGDB
DUX4L2
Tdark
Family:  TF
Novelty:  10.04651163
Score:  0.8
Data Source:  STRINGDB
DUX4L3
Tdark
Family:  TF
Novelty:  10.04651163
Score:  0.8
Data Source:  STRINGDB
DUX4L5
Tdark
Family:  TF
Score:  0.8
Data Source:  STRINGDB
DUX4L6
Tdark
Family:  TF
Novelty:  7.39047619
Score:  0.8
Data Source:  STRINGDB
FRG1
Tbio
Novelty:  0.0292811
Score:  0.798
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 104.62
PubMed score by year
PubTator Score 116.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title