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Tchem
CTSF
Cathepsin F

Protein Summary
Description
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310325
  • ENSP00000310832
  • ENSG00000174080

Symbol
  • CATSF
  • CLN13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
disease perturbation
0.93
kinase perturbation
0.76
histone modification site profile
0.73
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.04   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.04   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (24)
CHEMBL390474
Rendered image for CHEMBL390474
CHEMBL230474
Rendered image for CHEMBL230474
CHEMBL1288531
Rendered image for CHEMBL1288531
CHEMBL1288530
Rendered image for CHEMBL1288530
odanacatib
Rendered image for odanacatib
CHEMBL399361
Rendered image for CHEMBL399361
CHEMBL1288532
Rendered image for CHEMBL1288532
CHEMBL1288523
Rendered image for CHEMBL1288523
CHEMBL1290084
Rendered image for CHEMBL1290084
Protein-Protein Interactions (81)
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.999899595
p_ni:  0.000100405
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.999807512
p_ni:  0.000192484
p_wrong:  4e-9
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.999726746
p_ni:  0.000265819
p_wrong:  0.000007435
Data Source:  BioPlex
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.999485556
p_ni:  0.000501783
p_wrong:  0.000012662
Score:  0.403
Data Source:  BioPlex,STRINGDB
INSL5
Tbio
Novelty:  0.04351334
p_int:  0.99945164
p_ni:  0.000548359
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.999425958
p_ni:  0.000573966
p_wrong:  7.6e-8
Data Source:  BioPlex
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
p_int:  0.999371759
p_ni:  0.00062824
p_wrong:  1e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.999309315
p_ni:  0.000690684
p_wrong:  1e-9
Data Source:  BioPlex
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
p_int:  0.99929655
p_ni:  0.000703449
p_wrong:  1e-9
Data Source:  BioPlex
LY86
Tbio
Novelty:  0.00314575
p_int:  0.99556122
p_ni:  0.004436875
p_wrong:  0.000001905
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
65.7
apolipoprotein B measurement
2
2
2
65.7
insomnia measurement
1
1
0
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
65.7
apolipoprotein B measurement
2
65.7
insomnia measurement
0
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin F
VGNC:3139
746579
Macaque
cathepsin F
713743
Mouse
MGI:1861434
56464
Rat
RGD:1308181
361704
Dog
cathepsin F
VGNC:39711
476010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin F
Macaque
cathepsin F
Mouse
Rat
Dog
cathepsin F
Publication Statistics
PubMed Score 78.04
PubMed score by year
PubTator Score 32.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title