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Tbio
ZMYM2
Zinc finger MYM-type protein 2

Protein Summary
Description
May function as a transcription factor. The protein encoded by this gene is a zinc finger protein that may act as a transcription factor. The encoded protein may be part of a BHC histone deacetylase complex. Translocation of this gene with the fibroblast growth factor receptor-1 gene (FGFR1) results in a fusion gene, which may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382871
  • ENSP00000372324
  • ENSG00000121741
  • ENST00000382874
  • ENSP00000372327
  • ENST00000610343
  • ENSP00000479904

Symbol
  • FIM
  • RAMP
  • ZNF198
  • FIM
  • MYM
  • RAMP
  • SCLL
  • ZNF198
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.9
microRNA
0.81
transcription factor
0.76
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.2   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.2   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999946436
p_ni:  0.000053564
Data Source:  BioPlex
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999936344
p_ni:  0.000063656
Score:  0.637
Data Source:  BioPlex,STRINGDB
ZSCAN5A
Tdark
Family:  TF
Novelty:  2.15267128
p_int:  0.999238255
p_ni:  0.000761745
Score:  0.161
Data Source:  BioPlex,STRINGDB
PDGFRL
Tbio
Novelty:  0.0709225
p_int:  0.998770944
p_ni:  0.001229056
Data Source:  BioPlex
TRIM10
Tbio
Novelty:  0.27685659
p_int:  0.99753897
p_ni:  0.00246103
Score:  0.424
Data Source:  BioPlex,STRINGDB
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.997040821
p_ni:  0.002959179
Data Source:  BioPlex
ZNF202
Tbio
Family:  TF
Novelty:  0.06306212
p_int:  0.996786906
p_ni:  0.003213094
Score:  0.208
Data Source:  BioPlex,STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.995990299
p_ni:  0.004009701
Data Source:  BioPlex
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.986659906
p_ni:  0.013340094
Data Source:  BioPlex
C8A
Tbio
Novelty:  0.00429321
p_int:  0.983343222
p_ni:  0.016656778
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FGFR1 mutant receptor activation
Reactome
Signaling by FGFR in disease
Reactome
Signaling by FGFR1 in disease
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
FGFR1 mutant receptor activation
Signaling by FGFR in disease
Signaling by FGFR1 in disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
54.4
grip strength measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
54.4
grip strength measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger MYM-type containing 2
721255
Mouse
MGI:1923257
76007
Rat
RGD:1593255
305913
Dog
zinc finger MYM-type containing 2
VGNC:48646
477346
Horse
zinc finger MYM-type containing 2
VGNC:25250
100053589
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger MYM-type containing 2
Mouse
Rat
Dog
zinc finger MYM-type containing 2
Horse
zinc finger MYM-type containing 2
Publication Statistics
PubMed Score 39.20
PubMed score by year
PubTator Score 63.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title