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Tbio
BIN2
Bridging integrator 2

Protein Summary
Description
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000544402
  • ENSP00000445874
  • ENSG00000110934

Symbol
  • BRAP1
  • BRAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.64
tissue sample
0.63
protein domain
0.58
co-expressed gene
0.52
cell line
0.46


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.93   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.93   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
85.6
basophil percentage of leukocytes
1
1
1
9.3
basophil count
1
1
1
7.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
85.6
basophil percentage of leukocytes
1
9.3
basophil count
1
7.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3611448
668218
Rat
RGD:1306789
366988
Dog
bridging integrator 2
VGNC:38459
486539
Horse
bridging integrator 2
VGNC:15831
100060850
Cow
bridging integrator 2
VGNC:26498
515025
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
bridging integrator 2
Horse
bridging integrator 2
Cow
bridging integrator 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBW5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (93)
1 – 10 of 93
BIN1
Tbio
Novelty: 0.00312612
p_int: 1
Score: 0.988
Data Source: BioPlex,STRINGDB
AMPH
Tbio
Novelty: 0.00201043
p_int: 0.999999853
p_ni: 1.47e-7
Score: 0.818
Data Source: BioPlex,STRINGDB
KIF1B
Tbio
Novelty: 0.00984332
p_int: 0.999998896
p_ni: 0.000001049
p_wrong: 5.5e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
EFEMP1
Tbio
Novelty: 0.00574779
p_int: 0.990222554
p_ni: 0.00593445
p_wrong: 0.003842996
Score: 0.163
Data Source: BioPlex,STRINGDB
LCP1
Tbio
Novelty: 0.0035357
Score: 0.955
Data Source: STRINGDB
BIN3
Tbio
Novelty: 0.02034119
Score: 0.936
Data Source: STRINGDB
SYNJ1
Tbio
Novelty: 0.01030746
Score: 0.935
Data Source: STRINGDB
SYNJ2
Tbio
Novelty: 0.03679911
Score: 0.935
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.93
Data Source: STRINGDB
DNM1
Tbio
Novelty: 0.00319082
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.93

PubMed score by year
PubTator Score  29.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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