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Tbio
PEF1
Peflin

Protein Summary
Description
Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidences show that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed: ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373703
  • ENSP00000362807
  • ENSG00000162517

Symbol
  • ABP32
  • ABP32
  • PEF1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
kinase perturbation
0.76
molecular function
0.76
interacting protein
0.72
histone modification site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (73)
1 – 10 of 73
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.999999471
p_ni:  4.41e-7
p_wrong:  8.8e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
HIST2H2AB
Tbio
Novelty:  0.06772132
p_int:  0.851148598
p_ni:  0.148851353
p_wrong:  4.9e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
PDCD6
Tbio
Novelty:  0.0139857
Score:  0.978
Data Source:  STRINGDB
KLHL12
Tbio
Novelty:  0.05789229
Score:  0.965
Data Source:  STRINGDB
SEC31A
Tbio
Novelty:  0.0350228
Score:  0.965
Data Source:  STRINGDB
SEC31B
Tdark
Novelty:  0.35742768
Score:  0.944
Data Source:  STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.94
Data Source:  STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.938
Data Source:  STRINGDB
SEC24C
Tbio
Novelty:  0.05842956
Score:  0.932
Data Source:  STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.928
Data Source:  STRINGDB
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
15
7
5.8
84.4
self reported educational attainment
3
3
2
6.1
75.4
cognitive function measurement
3
2
3
68.5
body mass index
2
2
2
61.3
smoking status measurement
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
5.8
84.4
self reported educational attainment
2
6.1
75.4
cognitive function measurement
3
68.5
body mass index
2
61.3
smoking status measurement
2
56.4
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
penta-EF-hand domain containing 1
VGNC:9381
456701
Mouse
MGI:1915148
67898
Rat
RGD:1359536
297900
Dog
penta-EF-hand domain containing 1
VGNC:44412
611885
Horse
penta-EF-hand domain containing 1
VGNC:21303
100056122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
penta-EF-hand domain containing 1
Mouse
Rat
Dog
penta-EF-hand domain containing 1
Horse
penta-EF-hand domain containing 1
Publication Statistics
PubMed Score 55.04
PubMed score by year
PubTator Score 25.38
PubTator score by year