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Tbio
WNT16
Protein Wnt-16

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222462
  • ENSP00000222462
  • ENSG00000002745
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.7
biological process
0.66
pathway
0.63
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.1   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.1   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
7
3
9
99.5
heel bone mineral density
3
4
7
98.1
bone quantitative ultrasound measurement
1
1
1
77
cortical thickness
1
1
1
65.9
spine bone mineral density
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
9
99.5
heel bone mineral density
7
98.1
bone quantitative ultrasound measurement
1
77
cortical thickness
1
65.9
spine bone mineral density
1
63.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 16
VGNC:4564
737375
Macaque
Wnt family member 16
694069
Mouse
MGI:2136018
93735
Rat
RGD:1562253
500047
Dog
Wnt family member 16
VGNC:49699
612328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 16
Macaque
Wnt family member 16
Mouse
Rat
Dog
Wnt family member 16
Pathways (88)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (118)
1 – 10 of 118
PCBP3
Tbio
Novelty: 0.11681812
p_int: 0.997200768
p_ni: 0.002781195
p_wrong: 0.000018036
Score: 0.2
Data Source: BioPlex,STRINGDB
GALNS
Tbio
Family: Enzyme
Novelty: 0.00510529
p_int: 0.928132361
p_ni: 0.071867639
Score: 0.156
Data Source: BioPlex,STRINGDB
NR2F2
Tbio
Family: NR
Novelty: 0.00450561
p_int: 0.913677127
p_ni: 0.086322858
p_wrong: 1.5e-8
Score: 0.164
Data Source: BioPlex,STRINGDB
CANX
Tbio
Novelty: 0.00087002
p_int: 0.901689267
p_ni: 0.098310729
p_wrong: 4e-9
Data Source: BioPlex
WNT5A
Tbio
Novelty: 0.00125563
p_int: 0.89970123
p_ni: 0.056647034
p_wrong: 0.043651736
Score: 0.956
Data Source: BioPlex,STRINGDB
TOR3A
Tbio
Novelty: 0.11588309
p_int: 0.897825791
p_ni: 0.102174209
Score: 0.524
Data Source: BioPlex,STRINGDB
WLS
Tbio
Novelty: 0.01459149
p_int: 0.870608934
p_ni: 0.129391066
Score: 0.994
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.830278317
p_ni: 0.169721683
Data Source: BioPlex
N4BP2L2
Tbio
Novelty: 0.24527466
p_int: 0.77397902
p_ni: 0.221101208
p_wrong: 0.004919772
Data Source: BioPlex
WNT11
Tbio
Novelty: 0.0045754
p_int: 0.756860243
p_ni: 0.000460793
p_wrong: 0.242678964
Score: 0.937
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  100.10

PubMed score by year
PubTator Score  34.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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