You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SEL1L
Protein sel-1 homolog 1

Protein Summary
Description
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336735
  • ENSP00000337053
  • ENSG00000071537
  • ENST00000555824
  • ENSP00000450709

Symbol
  • TSA305
  • Hrd3
  • SEL1L1
  • PRO1063
  • SEL1-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.97
interacting protein
0.93
cell type or tissue
0.74
transcription factor binding site profile
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.96   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.96   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
AMIGO3
Tdark
Novelty:  7.6744186
p_int:  0.957591886
p_ni:  0.042408114
Score:  0.163
Data Source:  BioPlex,STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.87187067
p_ni:  0.12812933
Data Source:  BioPlex
FOXRED2
Tdark
Family:  Enzyme
Novelty:  0.33139597
p_int:  0.817576002
p_ni:  0.182423998
Score:  0.939
Data Source:  BioPlex,STRINGDB
RXYLT1
Tbio
Novelty:  0.14843707
p_int:  0.812564512
p_ni:  0.18743546
p_wrong:  2.9e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
CHST12
Tbio
Family:  Enzyme
Novelty:  0.04560641
p_int:  0.804553263
p_ni:  0.195446737
Score:  0.175
Data Source:  BioPlex,STRINGDB
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.790591174
p_ni:  0.209408826
Data Source:  BioPlex
CPA5
Tbio
Family:  Enzyme
Novelty:  0.0516555
p_int:  0.790366446
p_ni:  0.209633554
Score:  0.181
Data Source:  BioPlex,STRINGDB
TPSB2
Tchem
Family:  Enzyme
Novelty:  0.00757397
p_int:  0.784680779
p_ni:  0.215319221
Data Source:  BioPlex
SMPD1
Tchem
Family:  Enzyme
Novelty:  0.00199663
p_int:  0.779177263
p_ni:  0.220822737
Score:  0.226
Data Source:  BioPlex,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.777632712
p_ni:  0.222367288
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
77.4
corneal topography
1
1
1
76.3
platelet crit
2
2
2
70.4
glomerular filtration rate
2
2
2
54.2
lymphocyte count
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
77.4
corneal topography
1
76.3
platelet crit
2
70.4
glomerular filtration rate
2
54.2
lymphocyte count
2
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEL1L, ERAD E3 ligase adaptor subunit
VGNC:6787
453080
Macaque
SEL1L ERAD E3 ligase adaptor subunit
708651
Mouse
MGI:1329016
20338
Rat
RGD:620147
314352
Dog
SEL1L ERAD E3 ligase adaptor subunit
480409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEL1L, ERAD E3 ligase adaptor subunit
Macaque
SEL1L ERAD E3 ligase adaptor subunit
Mouse
Rat
Dog
SEL1L ERAD E3 ligase adaptor subunit
Publication Statistics
PubMed Score 96.96
PubMed score by year
PubTator Score 58.37
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title