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Tbio
SEL1L
Protein sel-1 homolog 1

Protein Summary
Description
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336735
  • ENSP00000337053
  • ENSG00000071537
  • ENST00000555824
  • ENSP00000450709

Symbol
  • TSA305
  • Hrd3
  • SEL1L1
  • PRO1063
  • SEL1-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.97
interacting protein
0.93
cell type or tissue
0.74
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.69   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.69   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (23)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Defective CFTR causes cystic fibrosis
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Defective CFTR causes cystic fibrosis
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (147)
1 – 10 of 147
AMIGO3
Tdark
Novelty: 2.4
p_int: 0.957591886
p_ni: 0.042408114
Score: 0.163
Data Source: BioPlex,STRINGDB
SLAMF1
Tbio
Novelty: 0.00121506
p_int: 0.87187067
p_ni: 0.12812933
Data Source: BioPlex
FOXRED2
Tdark
Family: Enzyme
Novelty: 0.66666667
p_int: 0.817576002
p_ni: 0.182423998
Score: 0.939
Data Source: BioPlex,STRINGDB
RXYLT1
Tbio
Novelty: 0.22815784
p_int: 0.812564512
p_ni: 0.18743546
p_wrong: 2.9e-8
Score: 0.167
Data Source: BioPlex,STRINGDB
CHST12
Tbio
Family: Enzyme
Novelty: 0.07210463
p_int: 0.804553263
p_ni: 0.195446737
Score: 0.175
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.24489796
p_int: 0.790591174
p_ni: 0.209408826
Data Source: BioPlex
CPA5
Tbio
Family: Enzyme
Novelty: 0.06404525
p_int: 0.790366446
p_ni: 0.209633554
Score: 0.181
Data Source: BioPlex,STRINGDB
TPSB2
Tbio
Family: Enzyme
Novelty: 0.01241014
p_int: 0.784680779
p_ni: 0.215319221
Data Source: BioPlex
SMPD1
Tbio
Family: Enzyme
Novelty: 0.00088337
p_int: 0.779177263
p_ni: 0.220822737
Score: 0.226
Data Source: BioPlex,STRINGDB
PSG8
Tdark
Novelty: 0.31837916
p_int: 0.777632712
p_ni: 0.222367288
Data Source: BioPlex
Publication Statistics
PubMed Score  90.69

PubMed score by year
PubTator Score  58.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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