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Tbio
MORF4L1
Mortality factor 4-like protein 1

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331268
  • ENSP00000331310
  • ENSG00000185787
  • ENST00000426013
  • ENSP00000408880
  • ENST00000558502
  • ENSP00000452808
  • ENST00000559345
  • ENSP00000452717

Symbol
  • MRG15
  • Eaf3
  • MEAF3
  • MRG15
  • FWP006
  • S863-6
  • HsT17725
  • MORFRG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
small molecule perturbation
1
hub protein
0.97
transcription factor binding site profile
0.96
virus perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.91   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.91   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
4
1.1
98
2
1
0
1.1
39.9
1
1
0
1.1
39.8
1
1
0
1.1
21.8
smoking status measurement
1
1
0
1.1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98
0
1.1
39.9
0
1.1
39.8
0
1.1
21.8
smoking status measurement
0
1.1
10.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mortality factor 4 like 1
VGNC:1914
740309
Macaque
mortality factor 4 like 1
711357
Mouse
MGI:1096551
21761
Rat
RGD:1307938
300891
Pig
mortality factor 4 like 1
100154823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mortality factor 4 like 1
Macaque
mortality factor 4 like 1
Mouse
Rat
Pig
mortality factor 4 like 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (239)
1 – 10 of 239
MRGBP
Tbio
Novelty: 0.09537142
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
MORF4L2
Tbio
Novelty: 0.09897629
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
EP400P1
Tdark
Novelty: 2.69614836
p_int: 0.999999996
p_ni: 3e-9
p_wrong: 1e-9
Score: 0.89
Data Source: BioPlex,STRINGDB
PHF12
Tbio
Family: Epigenetic
Novelty: 0.00240295
p_int: 0.999999989
p_ni: 9e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
KDM5A
Tchem
Family: TF; Epigenetic
Novelty: 0.00953355
p_int: 0.999999983
p_ni: 6e-9
p_wrong: 1.2e-8
Score: 0.91
Data Source: BioPlex,STRINGDB
MRFAP1L1
Tdark
Novelty: 0.87470289
p_int: 0.999999896
p_ni: 5e-9
p_wrong: 9.9e-8
Score: 0.78
Data Source: BioPlex,STRINGDB
EMSY
Tbio
Novelty: 0.02216272
p_int: 0.999999862
p_ni: 1.34e-7
p_wrong: 4e-9
Score: 0.836
Data Source: BioPlex,STRINGDB
BRD8
Tbio
Family: Epigenetic
Novelty: 0.09769287
p_int: 0.999999474
p_ni: 5.26e-7
Score: 0.992
Data Source: BioPlex,STRINGDB
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.999999376
p_ni: 6.24e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
p_int: 0.999999019
p_ni: 9.81e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  66.91

PubMed score by year
PubTator Score  27.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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