Tbio MORF4L1 Mortality factor 4-like protein 1

Protein Summary

Description

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.

Uniprot Accession IDs

• Q9UBU8
• B4DKN6
• B7Z6R1
• D3DW88
• O95899
• Q5QTS1
• Q6NVX8
• Q86YT7
• Q9HBP6
• Q9NSW5

Gene Name

• MORF4L1

Ensembl ID

• ENST00000331268
• ENSP00000331310
• ENSG00000185787
• ENST00000426013
• ENSP00000408880
• ENST00000558502
• ENSP00000452808
• ENST00000559345
• ENSP00000452717

Symbol

• MRG15
• Eaf3
• MEAF3
• MRG15
• FWP006
• S863-6
• HsT17725
• MORFRG15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
small molecule perturbation	1
hub protein	0.97
transcription factor binding site profile	0.96
virus perturbation	0.95

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Mortality Factor 4-like Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Mortality Factor 4-like Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Mortality Factor 4-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.92   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.92   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0