You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DBF4
Protein DBF4 homolog A

Protein Summary
Description
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265728
  • ENSP00000265728
  • ENSG00000006634
  • ENST00000413643
  • ENSP00000414083

Symbol
  • ASK
  • DBF4A
  • ZDBF1
  • ASK
  • CHIF
  • DBF4A
  • ZDBF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
PubMedID
0.83
transcription factor binding site profile
0.78
virus perturbation
0.76
gene perturbation
0.72


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.39   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.39   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DBF4 zinc finger
VGNC:4327
472668
Macaque
DBF4 zinc finger
705468
Mouse
MGI:1351328
27214
Rat
RGD:1305854
312046
Dog
DBF4 zinc finger
VGNC:39780
475219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DBF4 zinc finger
Macaque
DBF4 zinc finger
Mouse
Rat
Dog
DBF4 zinc finger
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBU7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (147)
1 – 10 of 147
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999785999
p_ni:  0.000213871
p_wrong:  1.31e-7
Score:  0.324
Data Source:  BioPlex,STRINGDB
CDC7
Tchem
Family:  Kinase
Novelty:  0.00435359
p_int:  0.999448184
p_ni:  0.000551816
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
p_int:  0.800418212
p_ni:  0.198616294
p_wrong:  0.000965494
Score:  0.252
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.766676261
p_ni:  0.233323739
Score:  0.19
Data Source:  BioPlex,STRINGDB
MCM4
Tchem
Novelty:  0.00604311
Score:  0.999
Data Source:  STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.999
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.998
Data Source:  STRINGDB
MCM3
Tbio
Novelty:  0.00593382
Score:  0.998
Data Source:  STRINGDB
ORC4
Tbio
Novelty:  0.01763127
Score:  0.996
Data Source:  STRINGDB
ORC5
Tbio
Novelty:  0.02264865
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  101.39

PubMed score by year
PubTator Score  46.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer