Tbio GHRL Appetite-regulating hormone

Protein Summary

Description

Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q9UBU3
• A8CF34
• A8CF38
• A8CF42
• A8DN29
• A8DN30
• Q86YP8
• Q8TAT9
• Q9H3R3

Gene Name

• GHRL

Ensembl ID

• ENST00000287656
• ENSP00000287656
• ENSG00000157017
• ENST00000335542
• ENSP00000335074
• ENST00000422159
• ENSP00000405464
• ENST00000429122
• ENSP00000414819
• ENST00000430179
• ENSP00000399922
• ENST00000437422
• ENSP00000416768
• ENST00000439975
• ENSP00000403725
• ENST00000449238
• ENSP00000388145
• ENST00000457360
• ENSP00000391406

Symbol

• MTLRP
• MTLRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease	0.76
cellular component	0.72
chemical	0.66
biological term	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7443.68   (req: < 5)

Gene RIFs: 818   (req: <= 3)

Antibodies: 842   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7443.68   (req: >= 5)

Gene RIFs: 818   (req: > 3)

Antibodies: 842   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0