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Tbio
GHRL
Appetite-regulating hormone

Protein Summary
Description
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287656
  • ENSP00000287656
  • ENSG00000157017
  • ENST00000335542
  • ENSP00000335074
  • ENST00000422159
  • ENSP00000405464
  • ENST00000429122
  • ENSP00000414819
  • ENST00000430179
  • ENSP00000399922
  • ENST00000437422
  • ENSP00000416768
  • ENST00000439975
  • ENSP00000403725
  • ENST00000449238
  • ENSP00000388145
  • ENST00000457360
  • ENSP00000391406

Symbol
  • MTLRP
  • MTLRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease
0.76
cellular component
0.72
chemical
0.66
biological term
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6823.86   (req: < 5)
Gene RIFs: 721   (req: <= 3)
Antibodies: 842   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6823.86   (req: >= 5)
Gene RIFs: 721   (req: > 3)
Antibodies: 842   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
4
91.6
eosinophil percentage of leukocytes
2
3
3
83.3
eosinophil percentage of granulocytes
1
1
1
40.7
self reported educational attainment
1
1
1
31.4
sum of eosinophil and basophil counts
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.6
eosinophil percentage of leukocytes
3
83.3
eosinophil percentage of granulocytes
1
40.7
self reported educational attainment
1
31.4
sum of eosinophil and basophil counts
1
28.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ghrelin and obestatin prepropeptide
VGNC:14243
100609092
Macaque
ghrelin and obestatin prepropeptide
574280
Mouse
MGI:1930008
58991
Rat
RGD:632283
59301
Dog
ghrelin and obestatin prepropeptide
VGNC:41209
403587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ghrelin and obestatin prepropeptide
Macaque
ghrelin and obestatin prepropeptide
Mouse
Rat
Dog
ghrelin and obestatin prepropeptide
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UBU3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Metabolism of proteins
Gene Ontology Terms (67)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (197)
1 – 10 of 197
FARSB
Tchem
Family:  Enzyme
Novelty:  0.09683467
p_int:  0.9684667
p_ni:  0.000231266
p_wrong:  0.031302034
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.924251518
p_ni:  0.062999796
p_wrong:  0.012748686
Data Source:  BioPlex
GHSR
Tclin
Family:  GPCR
Novelty:  0.00165638
Score:  0.989
Data Source:  Reactome,STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.973
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.961
Data Source:  STRINGDB
AGRP
Tbio
Novelty:  0.00147804
Score:  0.948
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.944
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.941
Data Source:  STRINGDB
MBOAT4
Tbio
Family:  Enzyme
Novelty:  0.01125747
Score:  0.932
Data Source:  Reactome,STRINGDB
PTPRN2
Tbio
Family:  Enzyme
Novelty:  0.00862854
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6823.86

PubMed score by year
PubTator Score  167.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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