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Tbio
GHRL
Appetite-regulating hormone

Protein Summary
Description
Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity). This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287656
  • ENSP00000287656
  • ENSG00000157017
  • ENST00000335542
  • ENSP00000335074
  • ENST00000422159
  • ENSP00000405464
  • ENST00000429122
  • ENSP00000414819
  • ENST00000430179
  • ENSP00000399922
  • ENST00000437422
  • ENSP00000416768
  • ENST00000439975
  • ENSP00000403725
  • ENST00000449238
  • ENSP00000388145
  • ENST00000457360
  • ENSP00000391406

Symbol
  • MTLRP
  • MTLRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease
0.76
cellular component
0.72
chemical
0.66
biological term
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7443.68   (req: < 5)
Gene RIFs: 721   (req: <= 3)
Antibodies: 842   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7443.68   (req: >= 5)
Gene RIFs: 721   (req: > 3)
Antibodies: 842   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 59
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0