Tbio DKK2 Dickkopf-related protein 2

Protein Summary

Description

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBU2
• A0AVE9
• B2R6S7
• Q9UIU3
• Dickkopf-2

Gene Name

• DKK2

Ensembl ID

• ENST00000285311
• ENSP00000285311
• ENSG00000155011

Symbol

• DKK-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.85
cell type or tissue	0.7
microRNA	0.69
disease	0.6
histone modification site profile	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.73   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 288   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.73   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

TGIF2LX

Tbio

Family:  TF

Novelty:  0.10755032

p_int:  0.999999496

p_ni:  5e-7

p_wrong:  4e-9

Data Source:  BioPlex

DSG4

Tbio

Novelty:  0.01599371

p_int:  0.987559441

p_ni:  0.012420856

p_wrong:  0.000019703

Data Source:  BioPlex

AHCYL2

Tbio

Family:  Enzyme

Novelty:  0.08695339

p_int:  0.984673353

p_ni:  0.015326647

Data Source:  BioPlex

DHRS4

Tbio

Family:  Enzyme

Novelty:  0.02992279

p_int:  0.982412327

p_ni:  0.017587406

p_wrong:  2.67e-7

Data Source:  BioPlex

SORL1

Tbio

Novelty:  0.00380895

p_int:  0.981031813

p_ni:  0.018968187

Data Source:  BioPlex

LRP5

Tbio

Novelty:  0.00089807

p_int:  0.960747167

p_ni:  0.039252829

p_wrong:  4e-9

Score:  0.982

Data Source:  BioPlex,STRINGDB

CENPB

Tbio

Novelty:  0.0036225

p_int:  0.945381399

p_ni:  0.054616123

p_wrong:  0.000002478

Data Source:  BioPlex

RSPRY1

Tdark

Novelty:  0.26883105

p_int:  0.938765237

p_ni:  0.060176704

p_wrong:  0.001058059

Data Source:  BioPlex

LRP1B

Tbio

Novelty:  0.01443405

p_int:  0.932906539

p_ni:  0.067093461

Data Source:  BioPlex

AHCYL1

Tchem

Family:  Enzyme

Novelty:  0.02176432

p_int:  0.925932569

p_ni:  0.074067431

Data Source:  BioPlex

Nearest Tclin Targets (1)

Explore Nearest Tclin Targets

Downstream (1)

1 – 1 of 1

GSK3B

Tclin

Family:  Kinase

KEGG Distance:  4

Common Pathways:  1

1: Wnt signaling pathway

Pathways (21)

Reactome (8)

KEGG (1)

PathwayCommons (8)

WikiPathways (4)

Disease (R-HSA-1643685)

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Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	6 targets	R-HSA-5339717
Reactome	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15 targets	R-HSA-3772470
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	6 targets	R-HSA-5339717
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15 targets	R-HSA-3772470
Signal Transduction	2704 targets	R-HSA-162582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (1)

Processes (4)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
co-receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
receptor antagonist activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	2	3	3		93.3
Alopecia	Orphanet_79364	1	2	2		57.1
androgenetic alopecia	EFO_0004191	1	1	0	1.3	37.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	3		93.3
Alopecia	Orphanet_79364	2		57.1
androgenetic alopecia	EFO_0004191	0	1.3	37.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Developmental protein
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal
Wnt signaling pathway

GWAS Trait Find Similar Targets

No Header	No Header
Alopecia
androgenetic alopecia
balding measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
skeleton phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dickkopf WNT signaling pathway inhibitor 2	VGNC:588	745875
Macaque	dickkopf WNT signaling pathway inhibitor 2		694869
Mouse	dickkopf WNT signaling pathway inhibitor 2	MGI:1890663	56811
Rat	dickkopf WNT signaling pathway inhibitor 2	RGD:1308639	295445
Dog	dickkopf WNT signaling pathway inhibitor 2	VGNC:39970	478502

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dickkopf WNT signaling pathway inhibitor 2
Macaque	dickkopf WNT signaling pathway inhibitor 2
Mouse	dickkopf WNT signaling pathway inhibitor 2
Rat	dickkopf WNT signaling pathway inhibitor 2
Dog	dickkopf WNT signaling pathway inhibitor 2

Publication Statistics

PubMed Score 79.73

PubMed score by year

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PubTator Score 44.93

PubTator score by year

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Related Publications

Text Mined References (42)

GeneRif Annotations (29)

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10

0 of 0

PMID	Year	Title