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Tbio
DKK2
Dickkopf-related protein 2

Protein Summary
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285311
  • ENSP00000285311
  • ENSG00000155011

Symbol
  • DKK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
cell type or tissue
0.7
microRNA
0.69
disease
0.6
histone modification site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.73   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.73   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
TGIF2LX
Tbio
Family:  TF
Novelty:  0.10755032
p_int:  0.999999496
p_ni:  5e-7
p_wrong:  4e-9
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.987559441
p_ni:  0.012420856
p_wrong:  0.000019703
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.984673353
p_ni:  0.015326647
Data Source:  BioPlex
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.982412327
p_ni:  0.017587406
p_wrong:  2.67e-7
Data Source:  BioPlex
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.981031813
p_ni:  0.018968187
Data Source:  BioPlex
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.960747167
p_ni:  0.039252829
p_wrong:  4e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
CENPB
Tbio
Novelty:  0.0036225
p_int:  0.945381399
p_ni:  0.054616123
p_wrong:  0.000002478
Data Source:  BioPlex
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.938765237
p_ni:  0.060176704
p_wrong:  0.001058059
Data Source:  BioPlex
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.932906539
p_ni:  0.067093461
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.925932569
p_ni:  0.074067431
Data Source:  BioPlex
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
3
3
93.3
1
2
2
57.1
1
1
0
1.3
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
93.3
2
57.1
0
1.3
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 2
VGNC:588
745875
Macaque
dickkopf WNT signaling pathway inhibitor 2
694869
Mouse
MGI:1890663
56811
Rat
RGD:1308639
295445
Dog
dickkopf WNT signaling pathway inhibitor 2
VGNC:39970
478502
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dickkopf WNT signaling pathway inhibitor 2
Macaque
dickkopf WNT signaling pathway inhibitor 2
Mouse
Rat
Dog
dickkopf WNT signaling pathway inhibitor 2
Publication Statistics
PubMed Score 79.73
PubMed score by year
PubTator Score 44.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title